The Effects of Dobutamine, Propranolol and Nitroglycerin on an Experimental Canine Model of Congestive Heart Failure.
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概要
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A new experimental model of acute congestive heart failure was established in open-chest dogs, and it was employed to examine the effects of dobutamine, propranolol and nitroglycerin. The model was induced by intracoronary administration of saponin, volume loading and intravenous infusion of methoxamine. Left ventricular end-diastolic pressure (LVEDP) increased from 7.9±0.6 to 24.2±:1.4 mmHg, and aortic blood flow (AoF) decreased from 0.89±0.06 to 0.53±0.041/min. Systemic vascular resistance (SVR) increased from 9618±585 to 16492±1213 dynes·sec/cm<SUP>5</SUP> and right atrial pressure (RAP) increased from 2.5±0.2 to 4.2±0.4 mmHg. Furthermore, V<SUB>max</SUB> decreased from 71.6±5.1 to 45.8±2.9 1/sec, and the time constant of left ventricular pressure decay (T) increased from 40.0±2.6 to 90.2±7.9 msec. These hemodynamic changes were stable for up to 80 min. Dobutamine improved cardiac function by increasing V<SUB>max</SUB> and by decreasing T. Consequently, dobutamine increased AoF and decreased LVEDP, while there was no change in SVR. Nitroglycerin reduced LVEDP, SVR and T; increased AoF; and did not change V<SUB>max</SUB>. Propranolol produced no improvement in the hemodynamics or cardiac function. These results indicate that the present congestive heart failure model is characterized by global left ventricular dysfunction with lowered cardiac output and increased peripheral vascular tone, and it is beneficial for evaluating the pharmacological properties of drugs for acute congestive heart failure.
- 公益社団法人 日本薬理学会の論文
著者
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Kido Hideaki
Second Department Of Internal Medicine University Of Tokyo
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Sugimoto Tsuneaki
Second Department Of Internal Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Univers
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Nakamura Fumitaka
Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Uchida Yasumi
Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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KAMIJO Takeshi
Chugai Pharmaceutical Co., Ltd.
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UCHIDA Yasumi
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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TOMARU Takanobu
Second Department of Internal Medicine and the Department of Pathology, Faculty of Medicine, University of Tokyo
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Kido Hideaki
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Yanagisawa Miwa
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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