Sympathetic Nerve Activity During Hypertension Produced by Vertebral Embolism

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Responses of the sympathetic nerves and the systemic arterial pressure to vertebral embolism were examined in rabbits anesthetized with α-chloralose under artificial respiration and the following results were obtained: 1. Following vertebral embolism, the systemic arterial pressure increased moderately at first followed by a slight decrease, then increased to much higher levels and returned gradually to the control levels, and thereafter it decreased to lower levels than the controls.2. The sympathetic discharge increased slightly and momentarily at the onset of hypertension (the phase of the first increase), decreased to lower levels than the control (the phase of decrease), then increased markedly (the phase of the second increase) and returned gradually to the control levels in most experiments under intact buffer nerves. The phase of the second increase corresponded nearly to the second rise in blood pressure. The phase of decrease in sympathetic discharge disappeared or became slight with repeating embolism or with elevating blood pressure to much higher levels. Also, it became slight or disappeared in most experiments done after resection of the buffer nerves.3. Both rhythmical and non-rhythmical impulses were recorded from the renal nerves. The former responded to vertebral embolism in somewhat different fashion from the latter.4. Following embolism, the afferent impulses from the right subclavian baroreceptor increased nearly in parallel with the arterial pressure. It was concluded that the sympathetic nerve showed various discharge patterns in response to vertebral embolism. It was supposed that the phase of decrease in sympathetic discharge was mainly due to reflex inhibition by the buffer nerves and that the excitation patterns of the sympathetic nerve following vertebral embolism were determined by the following factors: magnitude of the sympathetic nerve excitation, sympatho-inhibitory action of the buffer nerves, reactivity of the target organs of the sympathetic nerves and the control levels of both sympathetic nerve activity and blood pressure.
International Heart Journal刊行会の論文

Sympathetic Nerve Activity During Hypertension Produced by Vertebral Embolism

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