Left Ventricular Function and Power Distribution during Ejection Period in Patients with Cardiac Diseases

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概要

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• Left ventricular (LV) power output (PW) distribution during ejection period, and its relation to LV function were analyzed in 22 patients with valvular disease or cardiomyopathy, and also in 5 controls.The PW was calculated from LV pressure and LV volume change by ventriculography at every 20msec of the ejection period.The controls and those with idiopathic non-obstructive hypertrophic cardiomyopathy showed a higher PW in the early phase of ejection period, followed by a gradual decrease. In the cases of idiopathic obstructive hypertrophic cardiomyopathy, aortic insufficiency, and mitral insufficiency, greater PW was generated widely over the ejection period, but the distribution was greater during the middle phase of the period. The idiopathic congestive cardiomyopathy and combined valvular disease developed a greater PW in the late phase of the period. The peak PW was observed during the phase of greater PW distribution in each disorder.Five controls (EF_??_60%, SWI_??_5600ml•mmHg/M2) showed a greater PW (49±4% of the total PW)in the early phase of ejection period, 9 with loaded but compensated LV function (EF_??_60%, SWI>5, 600) (41±10%)in the middle third, and 9 with failed LV function (EF_??_60%) (41±14%) in the late third.An index (2/3PW) of PW distribution correlated with EF (r=0.73, p<0.05). Heart rate, systolic blood pressure, and LV end-diastolic pressure were not different among patients with different levels of EF.Our investigation provides data which suggest that the main PW distribution probably shifts from the early to the middle phase adaptively to ventricular load, but may move from the middle to the late phase in cases of LV failure.

• International Heart Journal刊行会の論文

著者

• Iizuka Masahiko

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• MURAO Satoru

  Second Department of Internal Medicine,University of Tokyo

• Serizawa Takashi

  Second Department of Internal Medicine

• UCHIDA Yasumi

  Second Department of Internal Medicine,University of Tokyo

• Kato Akihito

  Second Department of Internal Medicine Tokyo University School of medicine

• Morooka Shigenori

  2nd Dept. Of Internal Medicine Fac. Of Medicine Univ. Of Tokyo

• Morooka Shigenori

  2nd Dept. Of Intern. Med. Faculty Of Med. Univ. Of Tokyo

• Takabatake Yutaka

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Koide Tadashi

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Ozeki Katsuhiko

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• MOROOKA Shigenori

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Murao Satoru

  Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• TANAKA Shugo

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• KAKIHANA Masaaki

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Uchida Yasumi

  Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• UCHIDA Yasumi

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• KOIDE Tadashi

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

• OZEKI Katsuhiko

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

• TAKABATAKE Yutaka

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

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