Beneficial effects of coenzyme Q10 on impaired left ventricular performance in streptozotocin diabetic rats.

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概要

• 論文の詳細を見る

• Chronic effects of coenzyme Q10 (CoQ: 30mg/kg/day for 12 weeks) on cardiac performance in streptozotocin (45mg/kg) induced diabetic rats were examined. Cardiac performance was assessed using the isolated retrograde perfused isovolumically contracting heart model. Compared to age matched nondiabetic rats, decreases occurred in myocardial CoQ (25.8±3.3 vs. 31.9±2.7μg/ml*), AMP (0.9±0.7 vs. 2.0±0.4μg/mg*), Emax (37±14 vs. 80±38mmHg/μl/g**), an index of myocardial contractility, and LV diastolic chamber stiffness constant k (0.68±0.13 vs. 1.31±0.59g/μl*) in diabetic rats. Normalized left ventricular weight (2.97±0.23 vs. 2.51±0.21mg/g*) and volume (1.53±0.34 vs. 0.89±0.53μl/g*) and time constant of left ventricular pressure fall, T (32.0±8.0 vs. 19.7±2.6 ms*) increased in diabetes. In diabetic rats taking CoQ, myocardial CoQ (28.5±3.2μg/ml) and AMP (2.1±1.7μg/mg) were the same as control, and T (23.5±7.4ms*) was significantly shortened (mean±SD, *p<0.05, **p<0.01).To compensate for depressed myocardial contractility and relaxation, LV dilatation and increased LV mass occurred in diabetic rats. Exogenous CoQ increased myocardial CoQ content and improved myocardial relaxation in diabetic rats.

• International Heart Journal刊行会の論文

著者

• Iizuka Masahiko

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Serizawa Takashi

  Second Department of Internal Medicine

• Sugimoto Tsuneaki

  Second Department Of Internal Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Univers

• OHYA Tetsuo

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• OHTANI Yoshi

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• SUGIURA Seiryo

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• OKU Junji

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• MURAKAMI Toru

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

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