Effects of chronic administration of atrial natriuretic polypeptide on glomerular lesions in spontaneously hypertensive rats.
スポンサーリンク
概要
- 論文の詳細を見る
In order to investigate the effects of atrial natriuretic polypeptides (ANP) on hypertensive glomerular lesions, ANP was administered intravenously by osmotic minipumps to 20 15-week-old male spontaneously hypertensive rats (SHRs) in a sustained hypertensive stage. ANP was infused at the rate of 100ng/hour/rat (the ANP group). Saline was similarly administered to 19 age-matched SHRs (the control group). The rats were sacrificed on the seventh day. Semiquantitative evaluation of the renal tissue revealed no significant difference in glomerular sclerosis between the 2 groups. However, segmental hyalinosis in glomeruli was more accentuated in the ANP group than in the control group. As it is suggested that hyalinosis in glomeruli is related to the elevated intracapillary pressure, the results of the present work were in accordance with reports that ANP increases glomerular capillary pressure by preglomerular vasodilation and postglomerular vasoconstriction. It should be determined whether endogenous ANP works as an aggravating factor for glomerular injuries in the natural course of hypertension.
- International Heart Journal刊行会の論文
著者
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Kangawa Kenji
Second Division, Department of Medicine, Kyoto University School of Medicine, Kyoto, and Department
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HIRATA Yasunobu
Second Department of Internal Medicine, Faculty of Medicine
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Sugimoto Tsuneaki
Second Department Of Internal Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Univers
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Ishii Masao
Second Department Of Internaal Medicine Yokohama City University
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KIMURA Kenjiro
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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MATSUOKA Hiroaki
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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MATSUO Hisayuki
Second Department of Biochemistry, Miyazaki Medical College
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MATSUO Hisayuki
Second Department of Biochemistry, Miyazaki Medicine college
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DROZDOVA Galina
People's Friendship University, Medical Faculty, Department of Pathological Physiology
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KANGAWA Kenji
Second Department of Biochemistry, Miyazaki Medical College
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DROZDOVA Galina
People's Friendship University, Medical Faculty, Department of Pathological Physiology
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ISHII Masao
Second Department of Internal Medicine, Faculty of Medicine, Yokohama City University
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