Cardiac content and Plasma Concentration of Atrial Natriuretic Polypeptide (AN) in Spontaneously Hypertensive Rats (SHR) : THE 14th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
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概要
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The cardiac content and plasma concentration of atrial natriuretic polypeptide (ANP) in hypertensive rats were measured by using radioimmunoassay for ANP. The animals used in this study were young (5-week-old) and adult (12- to 14-week-old) spontaneously hypertensive rats (SHR), strokeprone SHR (SHR-SP) and normotensive control Wistar-Kyoto rats (WKY). Most immunoreactive ANP in the cardiac extract of the hypertensive rats (both SHR and SHR-SP) was found to be predominantly γ-form as well as that of WKY. Cardiac ANP content in adult SHR and SHR-SP was significantly lower than in adult WKY (p < 0.01), although there were no differences among three groups in young rats. Similar tendencies were also observed for plasma ANP concentration. The level of plasma in adult hypertensive rats was significantly lower or tended to be lower than in adult normotensive rats. Furthermore, a high negative correlation was present between blood pressure and cardiac ANP content (r=-0.748, p <0.01) and between blood pressure and plasma ANP concentration (r=-0.608, p < 0.01) in all adult rats but there were no such relationships in young rats. The present study suggests that atrial natriuretic polypeptide may contribute to the pathogenesis or maintenance of high blood pressure in the genetic hypertensive rats.
- 社団法人日本循環器学会の論文
- 1985-09-20
著者
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Kitamura Kazuo
First Department of Internal Medicine, University of Miyazaki
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Miyata Atsuro
The Second Department Of Biochemistry Miyazaki Medical College
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Miyata Atsuro
宮崎医科大学 第1内科
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Tanaka Kenjiro
First Department of Internal Medicine, Miyazaki Medical College
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Kitamura Kazuo
First Department Of Internal Medicine University Of Miyazaki
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Tanaka Kenjiro
1st. Dept. Int. Med. Miyazaki Med. Col.
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Tanaka Kenjiro
First Department Of Internal Medicine Miyazaki Medical College
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Kangawa Kenji
Second Division, Department of Medicine, Kyoto University School of Medicine, Kyoto, and Department
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Matsuo Hisayuki
Second Division, Department of Medicine, Kyoto University School of Medicine, Kyoto, and Department
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HIGA TOSHINOBU
First Department of Internal Medicine, Miyazaki Medical College
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MIYATA ATSURO
Second Department of Biochemistry, Miyazaki Medical College
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Tanaka K
1st. Dept. Int. Med. Miyazaki Med. Col.
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Higa Toshinobu
1st Dept. Of Intern. Med. Miyazaki Medical College
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Kitamura Kazuo
First Department Of Internal Medicine Miyazaki Medical College University Of Miyazaki
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Kitamura Kazuo
First Department Of Internal Medicine Miyazaki Medical College
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