Rapid Increase in Cardiac Adrenomedullin Gene Expression Caused by Acute Pressure Overload : Effect of the Renin-Angiotensin System on Gene Expression

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概要

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• To determine whether acute pressure overload (POL) can stimulate adrenomedullin (AM) production. the response of ventricular AM gene expression and plasma AM concentration to aortic banding was investigated in the rat. Furthermore, any link between AM expression and the renin-angiotensin system (RAS) enhanced by acute POL was examined using: a Ca channel blocker (manidipine). an angiotensin II type 1 receptor antagonist (candesartan), and an angiotensin-converting enzyme inhibitor (quinapril). Rats with acute POL produced by suprarenal aortic banding were studied 1, 5 and 14 days after surgery. Plasma AM concentrations in banded rats at day 1 increased 1.49-fold (p<0.01), then gradually declined to near the control level at day 14. Plasma AM concentrations correlated with plasma renin activity (PRA) (p<0.001). Adrenomedullin mRNA expression in the left ventricle (LV) increased 1.35-fold (p<0.05) at day 1. This increase was not significant at either 5 or 14 days after surgery. Adrenomedullin mRNA expression in the right ventricle on days 1 and 5 increased by 1.46-fold (p<0.05) and 1.52-fold (p<0.05), respectively. Candesartan, quinapril and manidipine reduced systolic blood pressure equally and activated PRA at day 1. However, augmented LV AM gene expression was suppressed completely by candesartan and quinapril, but remained unaffected by manidipine. In conclusion, POL induces a rapid increase in cardiac AM gene expression and in plasma AM concentrations. Cardiac AM transcription could therefore be partly regulated by RAS in suprarenal aortic banding rats.

• 社団法人日本循環器学会の論文
• 2002-03-20

著者

• Onitsuka Hisamitsu

  First Department of Internal Medicine, University of Miyazaki

• Imamura Takuroh

  First Department of Internal Medicine, University of Miyazaki

• Kitamura Kazuo

  First Department of Internal Medicine, University of Miyazaki

• Eto T

  Circulatory And Body Fluid Regulation Faculty Of Medicine University Of Miyazaki

• Kitamura K

  Division Of Circulatory And Body Fluid Regulation Faculty Of Medicine Department Of Internal Medicin

• Eto Tanenao

  First Department Of Internal Medicine Faculty Of Medicine University Of Miyazaki

• Imamura Takuroh

  Department Of Internal Medicine Circulatory And Body Fluid Regulation University Of Miyazaki

• Takenaga Makoto

  Department Of Internal Medicine Miyazaki Social Insurance Hospital

• Matsuo Takeshi

  First Department of Internal Medicine, University of Miyazaki

• Hirano Shuji

  First Department of Internal Medicine, Miyazaki Medical College

• Hirano Shuji

  First Department Of Internal Medicine Miyazaki Medical College

• Kihara Koichi

  Department Of Geriatric Medicine Osaka University Medical School

• Koiwaya Yasushi

  First Department of Internal Medicine, Miyazaki Medical College

• Kitamura Kazuo

  First Department Of Internal Medicine University Of Miyazaki

• KOIWAYA Yasushi

  宮崎医科大学 第一内科

• Koiwaya Yasushi

  First Department Of Internal Medicine Miyazaki Medical College

• Kito Katsumi

  Department Of Pathology Ehime University School Of Medicine

• Eto Tanenao

  First Department Of Internal Medicine Department Of Pathology Miyazaki Medical College

• Onitsuka Hisamitsu

  1st Department Of Internal Medicine Miyazaki University

• Onitsuka Hisamitsu

  First Department Of Internal Medicine Miyazaki Medical College

• Matsuo Takeshi

  Department Of Internal Medicine Miyazaki Social Insurance Hospital

• Kitamura Kazuo

  First Department Of Internal Medicine Miyazaki Medical College University Of Miyazaki

• Imamura Takuroh

  First Department Of Internal Medicine University Of Miyazaki

• Kitamura Kazuo

  First Department Of Internal Medicine Miyazaki Medical College

• Matsuo Takeshi

  First Department of Internal Medicine, Miyazaki Medical College

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