Interstitial Pneumonia Induced by Ticlopidine
スポンサーリンク
概要
- 論文の詳細を見る
A 67-year-old female non-smoker, who had been diagnosed with familial hypercholesterolemia associated with severe atherosclerosis of the coronary, carotid and vertebral arteries, developed interstitial pneumonia 4 months after initiating ticlopidine to inhibit platelet aggregation. The lymphocyte stimulation test by ticlopidine was positive and bronchoalveolar lavage fluid showed an increase in lymphocytes and a decrease in the CD4^+/8^+ ratio, suggesting potentially undesirable side effects of ticlopidine. Two months after ticlopidine therapy was discontinued and prednisolone therapy started, the interstitial pneumonia had almost completely resolved. Two patients, one with ticlopidine-associated bronchiolitis obliterans organizing pneumonia and the other with pneumonia with multiple nodules, have been reported to date and the present patient is the third reported case of ticlo-pidine-induced pneumonia. The incidence of this side effect may not be so high because approximately 20 years have passed since ticlopidine was first marketed in Japan, but because the drug is now widely prescribed, this serious clinical side effect should be considered.
- 社団法人日本循環器学会の論文
- 2002-07-20
著者
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Onitsuka Hisamitsu
First Department of Internal Medicine, University of Miyazaki
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Date Haruhiko
First Department of Internal Medicine, University of Miyazaki
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Imamura Takuroh
First Department of Internal Medicine, University of Miyazaki
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Eto Tanenao
First Department Of Internal Medicine Faculty Of Medicine University Of Miyazaki
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Nagoshi Toshiro
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki
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Ishikawa Tetsunori
First Department of Internal Medicine, University of Miyazaki, University of Miyazaki
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Imamura Takuroh
Department Of Internal Medicine Circulatory And Body Fluid Regulation University Of Miyazaki
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Nagoshi Toshiro
First Department Of Internal Medicine Miyazaki Medical College University Of Miyazaki
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Date Haruhiko
1st Department Of Internal Medicine Miyazaki University
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Takenaga Makoto
Department Of Internal Medicine Miyazaki Social Insurance Hospital
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Matsuo Takeshi
First Department of Internal Medicine, University of Miyazaki
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Nakamura Ryosai
First Department of Internal Medicine, University of Miyazaki
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Nakamura Ryosai
First Department Of Internal Medicine University Of Miyazaki
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Ishikawa Tetsunori
Department Of Internal Medicine Miyazaki Social Insurance Hospital
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Koiwaya Yasushi
First Department of Internal Medicine, Miyazaki Medical College
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KOIWAYA Yasushi
宮崎医科大学 第一内科
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Koiwaya Yasushi
First Department Of Internal Medicine Miyazaki Medical College
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Fujiura Yoshitake
First Department of Internal Medicine, Miyazaki Medical College
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Imamura Takuroh
Institute Of Angiocardiology And Cardiovascular Clinic Kyusyu University
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Maeno Masakazu
First Department of Internal Medicine, Miyazaki Medical College
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Maeno Masakazu
First Department Of Internal Medicine Miyazaki Medical College
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Eto Tanenao
First Department Of Internal Medicine Department Of Pathology Miyazaki Medical College
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Mishima Kazuya
First Department of Internal Medicine, Miyazaki Medical College
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Onitsuka Hisamitsu
1st Department Of Internal Medicine Miyazaki University
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Onitsuka Hisamitsu
First Department Of Internal Medicine Miyazaki Medical College
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Mishima Kazuya
First Department Of Internal Medicine Miyazaki Medical College
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Matsuo Takeshi
Department Of Internal Medicine Miyazaki Social Insurance Hospital
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Imamura Takuroh
First Department Of Internal Medicine University Of Miyazaki
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Fujiura Yoshitake
First Department Of Internal Medicine Miyazaki Medical College
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Matsuo Takeshi
First Department of Internal Medicine, Miyazaki Medical College
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