Relations of Vascular Calcium Channels with Blood Pressure and Endothelium in Hypertension and with Aging.
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the relationships between the activity in potential operated Ca<SUP>2+</SUP> channels (POC), blood pressure, and endothelium in hypertension, we tested the contractile responses to a Ca<SUP>2+</SUP> channel agonist Bay K 8644 (BAY K) in aorta from deoxycorticosterone-acetate-saline (DOCA-S) and reduced renal mass-saline (RRM-S) hypertensive rats. The effects of mechanical rubbing, Nω-Nitro-L-Arginine Methyl Ester (l-NAME) and indomethacin were also examined. Sensitivity to BAY K increased in experimental rats before they became hypertensive and contractile responses were enhanced as hypertension developed. Force development to BAY K was correlated with blood pressure levels. Endothelium removal enhanced the contractile response to BAY K. L-NAME, but not indomethacin, potentiated the response to BAY K. Contractile response to BAY K was negatively correlated with relaxation to acetylcholine. An enhanced contractile response to BAY K was observed also in aged rats. Enhanced activation of vascular POC in hypertension results from elevated blood pressure and partly from diminished inhibitory action of endothelium. Senescence also enhances vascular POC activity.
- International Heart Journal刊行会の論文
著者
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Omata Masao
Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Sugimoto Tsuneaki
Second Department Of Internal Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Univers
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Nagoshi Hiroshi
Second Department Of Internal Medicine Graduate School Of Medicine The University Of Tokyo
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Hui Chen
Second Department Of Internal Medicine Faculty Of Medicine The University Of Tokyo
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GOTO Atsuo
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Yamada Kaoru
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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GOTO Atsuo
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
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YAMADA Kaoru
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
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YAGI Noriko
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
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SASABE Masao
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
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NAGOSHI Hiroshi
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
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SUGIMOTO Tsuneaki
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
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OMATA Masao
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
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