Local Delivery of Heparin Inhibits Neointimal Hyperplasia in Injured Rabbit Artery.
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概要
- 論文の詳細を見る
The efficacy of local delivery of an antithrombotic drug on neointimal hyperplasia was investigated in 17 rabbits. One rabbit iliac artery was injured by a balloon catheter as a control injured artery. The other iliac artery was also injured and treated by local delivery of 25U/kg of heparin. One hour after the balloon injury, angioscopy demonstrated an occlusive or mural thrombus in all the controls, but few in the locally-treated arteries. Four weeks after balloon injury, the percent stenosis was 34±31% in the heparin treated group (n=7, p<0.005 vs control side 73±17%). Accumulation of FITC-labeled heparin at the injured site was confirmed by microscopy. The activated partial thromboplastin time and fibrinogen level did not change significantly. PDGF-B chain was prominent at the neointimal layer in all the controls, whereas it was less in the locally treated arteries. Thus local delivery of heparin can inhibit neointimal hyperplasia after balloon injury by reducing thrombus-related growth stimulation. (Jpn Heart J 36: 657-668, 1995)
- International Heart Journal刊行会の論文
著者
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Omata Masao
Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Nakamura Fumitaka
Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Yoshimura Ashio
Department Of Medicine Division Of Nephrology Showa University Fujigaoka Hospital
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Uchida Yasumi
Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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OMATA Masao
Second Department of Internal Medicine, University of Tokyo
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TOMARU Takanobu
Second Department of Internal Medicine and the Department of Pathology, Faculty of Medicine, University of Tokyo
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TOMARU Takanobu
Second Department of Internal Medicine, University of Tokyo
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INUI Kiyoko
Department of Internal Medicine, Showa University Fujigaoka Hospital
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YOSHIMURA Ashio
Department of Internal Medicine, Showa University Fujigaoka Hospital
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