Left Ventricular Performance during the Infusion of Isoproterenol in Patients with Valvular Heart Diseases and Idiopathic Cardiomegaly

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概要

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• Hemodynamic responses to the infusion of isoproterenol were studied in 21 patients using right and left heart catheterization. With the measurement of intracardiac pressure, the left ventricular volume was caluculated by the radioisotope dilution method of external monitoring. The patients were divided into four groups: 6 cases of mitral stenosis, 6 cases of mitral stenosis and aortic regurgitation, 5 cases of mitral and/or aortic regurgitation, and 4 cases of idiopathic cardiomegaly.During the infusion of isoproterenol heart rate, cardiac index, mean systolic ejection rate and left ventricular minute work increased, and peripheral vascular resistance, stroke index and left ventricular stroke work decreased. Systemic blood pressure did not change. Left ventricular enddiastolic pressure and volume decreased with the increase in circumferential shortening rate.In those with mitral stenosis, pulmonary and left atrial pressure increased markedly, resulting in an increase in the pressure gradient between the left atrium and ventricle. In those with mitral stenosis and aortic regurgitation, the elevation of pulmonary and left atrial pressure occurred less markedly than in those with mitral stenosis. Pressure changes in those with mitral and/or aortic regurgitation were not marked, and cardiac index decreased in 3 of 5 cases. In those with idiopathic cardiomegaly one case showed marked systolic pressure gradient at the outflow tract of the left ventricle during the infusion.These hemodynamic effects are attributed to the strong positive chronotropic and inotropic action of isoproterenol as well as to the reduction of peripheral vascular resistance.

• International Heart Journal刊行会の論文

著者

• Ueda Hideo

  2nd Dept. Of Intern. Med. Univ. Of Tokyo

• Yasuda Hisakazu

  Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo:dokkyo Medical Colleg

• Ito Iwao

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Takabatake Yutaka

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Koide Tadashi

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Sugishita Yasuro

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Ozeki Katsuhiko

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Ueda Hideo

  Second Dept. Of Intern. Med. University Of Tokyo School Of Med.

• Nakanishi Atsuo

  Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo:dokkyo Medical Colleg

• Uchida Yasumi

  Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• SUGIURA Masaya

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• UEDA Keiji

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• MACHIDA Kikuo

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Ueda Hideo

  Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• UCHIDA Yasumi

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

• UEDA Keiji

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

• YASUDA Hisakazu

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

• KOIDE Tadashi

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

• NAKANISHI Atsuo

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

• OZEKI Katsuhiko

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

• TAKABATAKE Yutaka

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

• SUGISHITA Yasuro

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

• SUGIURA Masaya

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

• ITO Iwao

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

• ITO Iwao

  Second Department of Internal Medicine and the Department of Thoracic Surgery, Faculty of Medicine, University of Tokyo

• MACHIDA Kikuo

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

• UEDA Hideo

  Second Department of Internal Medicine, Faculty of Medicine University of Tokyo

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