Follow-up Study of Renal Blood Flow in Patients with Essential Hypertension : Changes in Those under Natural Course and under Antihypertensive Treatment
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概要
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Follow-up study of renal blood flow in patients with essential hypertension was made in 61 cases under natural course (Group I) and in 66 cases under continuous antihypertensive treatment (Group II). (1) The survey of renal blood flow changes in patients under natural course (Group I) revealed that: i) the average control renal blood flow of 661ml./min. with a range of 102 to 1, 350ml./min. decreased to 506ml./min. with a range of 35 to 1, 330ml./min. (24% decrease on an average), after averaged 35 months of follow-up period with a range of 7 months to 8 years; ii) a significant "decrease" in follow-up renal blood flow (more than 20% decrease of the control value) was found in 31 (51%) of 61 cases, "no change" in 26 (42%) and an "increase" in 4 (7%). (2) The survey in Group I was analysed in relation to various factors including sex, age, retinal finding, values of renal blood flow and blood pressure, and period of follow-up time. The conclusions which were drawn from the results of the analyses were: i) the initial severities of retinal finding, renal blood flow, and blood pressure may not always be indicative of the degree of succeeding renal blood flow changes; ii) reduction of renal blood flow mainly reflects the preceding blood pressure; iii) succeeding renal blood flow change is closely related with succeedingly sustained blood pressure level; iv) the effect of perisistent elevation of blood pressure is aggravated in advanced age. (3) From the comparative study of the results in Group II with those in Group I, practical conclusion was drawn that the same degree of renal blood flow change may be expected from succeeding low level of blood pressure irrespective of its spontaneous or therapy induced nature. (4) The survey of consecutive renal blood flow changes in Group II revealed a "decrease" in 29%, "no change" in 49%, and an "increase" in 22% of 144 determinations, indicating a distinct difference from the survey in Group I, especially in less than 3 years of follow-up observations. (5) Discussions were made on the observations of prognostic pattern of renal blood flow under natural course and on the comparative analyses with the survey of renal blood flow change under continuous antihypertensive treatment.
著者
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Takeuchi Jugoro
Second Department of Internal Medicine, Tokyo Medical And Dental University
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Ueda Hideo
Second Dept. Of Intern. Med. University Of Tokyo School Of Med.
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Takauchi Jugoro
2nd Division Dept. Of Intern. Med. Tokyo Univ. Sch. Of Med. And 1st Division Dept Of Intern. Med. Ka
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TAKEDA Tadanao
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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NAKAJIMA Kouji
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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IKEDA Takao
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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SUZUKI Keigo
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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NAKAYAMA Shosaku
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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INOUE Gosuke
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Ueda Hideo
Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Takeuchi J.
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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TAKEDA Tadanao
Second Department of Internal Medicine and the Department of Thoracic Surgery, Faculty of Medicine, University of Tokyo
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