Treatment of Hypertension with KK-25-S, a New Potent Ganglionic Blocking Agent
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概要
- 論文の詳細を見る
Antihypertensive effect of KK-25-S, a new potent ganglionic blocking agent, was evaluated in patients with moderate to severe essential hypertension. In 7 subjects, hypotensive responses after single oral dose were tested. Significant blood pressure reduction occurred within one or 2 hours after the administration of the drug and persisted for 4 hours or more. Thirty-two patients were treated with KK-25-S for periods of 2 to 29 weeks. Seven of 9 patients treated with KK-25-S alone failed to maintain significant hypotensive effect, whereas in 20 of 26 patients who received KK-25-S combined with other hypotensive drugs, significant blood pressure reduction was maintained throughout the treatment. Side-effects of the drug due to parasympathetic blockade were seen but readily controlled. Postural hypotension was relatively infrequent and slight in degree. Comparative studies on hypotensive potencies were made among different ganglionic blocking agents. It is concluded that KK-25-S is a potent hypotensive drug and is useful for the treatment of hypertension.
- International Heart Journal刊行会の論文
著者
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Takeuchi Jugoro
Second Department of Internal Medicine, Tokyo Medical And Dental University
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Ueda Hideo
Second Dept. Of Intern. Med. University Of Tokyo School Of Med.
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Takauchi Jugoro
2nd Division Dept. Of Intern. Med. Tokyo Univ. Sch. Of Med. And 1st Division Dept Of Intern. Med. Ka
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TAKEDA Tadanao
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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IKEDA Takao
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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UCHIDA Eiichi
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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NAKAYAMA Shosaku
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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YAGI Shigeru
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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NAKAJIMA Koji
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Ueda Hideo
Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Takeuchi J.
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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TAKEDA Tadanao
Second Department of Internal Medicine and the Department of Thoracic Surgery, Faculty of Medicine, University of Tokyo
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