Experimental Vascular Lesions in Desoxycorticosterone Hypertension in Rats

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A series of the DCA-treated rats were unilaterally nephrectomized, given 1% NaCl solution for drinking fluid, and killed periodically to observe the evolution and progress of vascular lesions in relation to the elevation of blood pressure.(1) Acute necrotizing vascular damage appeared in bursts in the early period of DCA treatment. The evolution of lesions diminished thereafter while interstitial cells and fibers proliferated in the areas involved and continuously accumulated in parallel with time. In the kidney, lesions further extended with destruction of the glomeruli and tubules secondary to vascular damage.(2) The necrotizing vascular damage evoluted in the period when blood pressure was elevating rapidly. The histological features and localization of lesions highly suggest that the rise in blood pressure, which results in altered vascular permeability, and the status of the musculature of the peripheral vascular bed related to some maldistribution of sodium ion are of fundamental importance in the pathogenesis of the damage.(3) On the other hand, the fact that the evolution of the damage diminished in the period when hypertension became established points out that high blood pressure is not an only dertermning factor.
International Heart Journal刊行会の論文