Myocardial Distribution of Blood Flow in the Dog, Studied by the Labeled Microsphere:Part II. Heterogeneity of Myocardial Blood Flow in Left Ventricle Induced by Isoproterenol Injection

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In dogs anesthetized with sodium pentobarbital, myocardial distribution of blood flow was measured by injecting "carbonized microspheres" labeled with Sr-85 or Ce-141 into left atrium. The changes of myocardial segment length was also measured by 2 strain gauge arches sutured on the apical and basal portions of left ventricular surface.In the control state, homogeneous myocardial distribution of blood flow was observed in the left ventricle. One and half min. after injecting 2μg./Kg. of isoproterenol, myocardial blood flow decreased in the endocardial side, which was marked in the apical portion, while it increased slightly in the epicardial side. The contraction of the myocardium increased at the apical portion and decreased at the basal portion. Five min. after the injection of isoproterenol, myocardial blood flow at the endocardial side of the anterior apical portion increased, whereas other parameters measured returned toward the control levels.The relation between heterogeneous distribution of myocardial blood flow and the heterogeneous contraction of myocardium was discussed.
International Heart Journal刊行会の論文