Myocardial Distribution of Blood Flow in the Dog, Studied by the Labeled Microsphere:Part I. Method

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In 5 anesthetized dogs, "carbonized microsphere" labeled with Sr-85 was injected into left atrium, and then the heart was excised and divided into 4 heart chambers and interventricular septum. Total and regional myocardial blood flow was calculated from the relative distribution of radioactivity, the weight of each myocardium samples and cardiac output, by the principle that the injected microspheres are distributed in the heart in proportion to the distribution of the regional myocardial blood flow. Total myocardial blood flow was 5.35±1.00% of the cardiac output, and the average myocardial flow per 100Gm. of the myocardium was 76.3±15.5ml./min./100Gm. Right ventricle was supplied significantly less blood flow than left ventricle. The blood flow in the basal portion of right ventricle was less than that in the apical. There was no significant difference among the perfusion areas of left ventricle, but endocardial side of left ventricle was supplied with more flow than epi-cardial side. Interventricular septum had a similar pattern of flow distribution to left ventricular free wall. The total coronary sinus flow was collected during the injection of the microspheres using a cannula introduced into coronary sinus via right auricular appendage, and no significant coronary arteriovenous shunt was found.
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