EFFECT OF PROSTAGLANDIN I_2 ON CYCLICAL REDUCTIONS OF CORONARY BLOOD FLOW

概要

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The effects of prostaglandin (PG) I_2 and the agents which affect PG and thromboxane (TX) generating systems on cyclical reductions of blood flow in the partially constricted coronary artery of anesthetized dogs were examined. Cyclical reductions were eliminated by PG I_2, but not by PG D_2, and were augmented by 15-hydroperoxy arachidonic acid and tranylcypromine that inhibited synthesis of PG I_2. The cyclical reductions were also eliminated by Cu-chlorophylline that inhibited synthesis of PG E_2 and accelerated synthesis of TX A_2, but were not by imidazole and 1-methyl imidazole that inhibited synthesis of TX A_2. The results in this and in the previous studies indicate synthesis of TX A_2 but PG E_2 participates as an inducer while PG I_2 participates as an inhibitor in cyclical reductions of coronary blood flow.
社団法人日本循環器学会の論文
1979-08-20