Physiological Significance of Atrial Natriuretic Peptides in Essential Hypertension : SYMPOSIUM ON ATRIAL NATRIURETIC POLYPEPTIDE (ANP): Basic and Clinical Research : 51th Annual Scientific Session of the Japanese Circulation Society
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概要
- 論文の詳細を見る
To investigate the significance of atrial natriuretic peptides (ANP) in essential hypertension, plasma ANP concentrations in 43 essential hypertensives, 16 borderline hypertensives and 17 normotensive controls were measured. Furthermore, effects of high-sodium and low-sodium intakes on plasma ANP concentration were examined in "salt-sensitive" [SS] and "nonsalt-sensitive" [NSS] patients with essential hypertension. Plasma ANP concentration was significantly higher in hypertensives than in borderline hypertensives and in normotensive controls. No significant difference in plasma ANP concentration was observed between borderline hypertensives and normotensive controls. Plasma ANP concentration increased with the high-sodium diet in both the SS and NSS patients, but the mean increment was significantly greater in the SS than the NSS patients. Urinary excretion of sodium was lower in the SS patients taking the high-sodium diet than the coresponding value in the NSS patients. These findings suggest that an increased level of circulating ANP in hypertensive patients represents a compensatory mechanism to offset further elevation of blood pressure and sodium retention.
- 社団法人日本循環器学会の論文
- 1988-12-20
著者
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Kohno Masakazu
Dep. Of Cardiorenal And Cerebrovascular Medicine Kagawa Univ.
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Akioka Kaname
First Department of Internal Medicine Osaka City University Medical School
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Teragaki Masakazu
First Department of Internal Medicine Osaka City University Medical School
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Takeuchi Kazuhide
First Department of Internal Medicine Osaka City University Medical School
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Takeuchi Kazuhide
大阪市立大学 医学研究科循環器病態内科学
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Takeda Tadanao
First Department of Internal Medicine, Osaka City University Medical School
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Oku Hisao
The 1st Department Of Internal Medicine Osaka City University Medical School
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Takeda Tadanao
First Department Of Internal Medecine Osaka City University Medical School
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Kohno Masakazu
First Department Of Internal Medicine Osaka City University Medical School
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Kohno Masakazu
First Department Of Internal Medecine Osaka City University Medical School
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YASUNARI Kenichi
First Department of Internal Medicine, Osaka City University, Medical School
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YOKOKAWA Koji
First Department of Internal Medicine, Osaka City University, Medical School
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Nishikimi Toshio
First Department Of Internal Medicine Osaka City University Medical School
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Yasuda Mitsutaka
The 1st Department Of Internal Medicine Osaka City University Medical School
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YASUDA MITSUTAKA
First Department of Internal Medicine, Osaka City University Medical School
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OKU HISAO
First Department of Internal Medicine, Osaka City University Medical School
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MURAKAWA KOH-ICHI
First Department of Internal Medicine, Osaka City University Medical School
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Murakawa Koh-ichi
1st Department Of Internal Medicine Osaka City University Medical School
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Yasunari Kenichi
First Department Of Internal Medicine Osaka City University Medical School
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Yokokawa Koji
The First Department Of Internal Medicine Osaka City University Medicial School
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Oku Hisao
First Department Of Internal Medicine Osaka City University Medical School
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