Novel Method for Assessing Myocardial Perfusion : Visualization and Measurement of Intramyocardial Coronary Blood Flow in the Entire Left Ventricular Wall Using Contrast Enhanced, High Frequency Doppler Echocardiography

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概要

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• Using a high frequency ultrasonic transducer, intramyocardial coronary blood flow (IM-CBF) can be visualized and evaluated during hemodynamic changes in the anterior wall and septum of the left ventricle (LV). We tested the hypothesis that detection and quantitative measurement of IM-CBF of entire LV segments are feasible using a high frequency ultrasonic transducer in conjunction with intravenous contrast injection in vivo. A 3 - 8 MHz transducer was used to image and measure IM-CBF in 10 anesthetized dogs. We obtained a color Doppler image of IM-CBF in the LV short-axis view after intravenous Levovist(TM) injection (25 mg / ml). The IM-CBF velocity was recorded using spectral Doppler in the antero-septal and infero-posterior wall of closed chest dogs and in the entire LV after opening the chest. A significant increase in IM-CBF velocity was observed in all LV regions after adenosine 5- triphosphate (ATP) administration. After Levovist(TM) injection, the visualization of IM-CBF was improved and the spectral Doppler pattern of coronary flow velocity was clarified compared to baseline. IM-CBF was assessed in the antero-septal region of the LV before and after left anterior descending coronary artery occlusion. A high frequency ultrasonic transducer in conjunction with intravenous contrast injection improved IM-CBF visualization, enabling quantitative evaluation of the intramyocardial coronary circulation in the entire LV after coronary occlusion and hyperemia. This study may represent a step towards noninvasive assessment of myocardial perfusion before and after coronary reperfusion.

• Japanese Heart Journal Associationの論文

著者

• Itabe Hiroyuki

  大阪市立大学 医学研究科肝胆膵病態内科

• Yoshiyama Minoru

  First Department of Internal Medicine Osaka City University Medical School

• Teragaki Masakazu

  First Department of Internal Medicine Osaka City University Medical School

• Takeuchi Kazuhide

  First Department of Internal Medicine Osaka City University Medical School

• Yoshikawa Junichi

  First Department of Internal Medicine Osaka City University Medical School

• Ujino Keiji

  First Department of Internal Medicine, Osaka City University Medical School

• Ota Takahiro

  First Department of Internal Medicine, Osaka City University Medical School

• Muro Takashi

  First Department of Internal Medicine, Osaka City University Medical School

• Watanabe Hiroyuki

  First Department of Internal Medicine, Osaka City University Medical School

• Ota Takahiro

  府中病院

• Watanabe Hiroyuki

  First Department Of Internal Medicine And Clinical Pathology Showa University School Of Medicine

• TAKEUCHI Kazuhide

  First Department of Internal Medicine, Osaka City University Medical School

• Yoshiyama Minoru

  First Department of Internal Medicine, Osaka City University Medical School

• Yoshikawa Junichi

  First Department of Internal Medicine, Osaka City University Medical School

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