Assessment of Cardiac Function and Gene Expression at an Early Phase after Myocardial Infarction.
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概要
- 論文の詳細を見る
The purpose of this study was to examine left ventricular function and cardiac gene expressions at an acute phase after myocardial infarction (MI). MI was induced in rats by ligation of the left coronary artery. Two days after MI, we performed Doppler-echocardiography and measured the systolic and diastolic function. We then analyzed the contractile protein and extracellular matrix mRNAs of cardiac tissues in the infarcted region, including the adjacent noninfarcted myocardium (the adjacent noninfarcted myocardium) and the remote noninfarcted myocardium, by Northern blot hybridization. Fractional shortening decreased significantly to 28%. Peak early diastolic filling wave (E wave) velocity increased in MI rats (MI; 90±3cm/s versus the control; 71±2cm/s, p<0.05), and the deceleration rate of the E wave velocity was more rapid in MI rats (MI; 22.0±2.6m/s2 versus the control; 16.5±2.0m/s2, p<0.01). Atrial filling wave (A wave) velocity decreased, resulting in a marked increase in the ratio of E wave to A wave velocity (MI; 3.1±0.3 versus the control; 2.1±0.2, p<0.01). In the adjacent noninfarcted myocardium, mRNA levels for Α-skeletal actin, atrial natriuretic polypeptide (ANP), transforming growth factor-β1(TGF-β1), fibronectin, and collagen types I and III increased significantly. In the remote noninfarcted myocardium, mRNA levels for α-skeletal actin, ANP, and collagen types I and III increased, while mRNA levels for β-myosin heavy chain, TGF-β1 and fibronectin did not change. We observed left ventricular dysfunction and different gene expressions between adjacent noninfarcted myocardium and in the remote noninfarcted myocardium two days after MI. These findings suggest that cardiac gene expression after MI may be a compensation reaction for cardiac dysfunction induced by myocardial damage.
- International Heart Journal刊行会の論文
著者
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Yoshiyama Minoru
First Department of Internal Medicine Osaka City University Medical School
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Takeuchi Kazuhide
First Department of Internal Medicine Osaka City University Medical School
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Yoshikawa Junichi
First Department of Internal Medicine Osaka City University Medical School
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HANATANI Akihisa
First Department of Internal Medicine, Osaka City Unitersity Medical School
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OMURA Takashi
First Department of Internal Medicine, Osaka City Unitersity Medical School
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Iwao Hiroshi
Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine
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Kim Shokei
Department Of Internal Medicine And Cardiology Osaka City University Medical School
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Kim Shokei
Department of Pharmacology, Osaka City University Medical School
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IKUNO Yoshiyasu
Tane General Hospital Osaka City University Medical School
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HANATANI Akihisa
First Department of Internal Medicine Osaka City University Medical School
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OMURA Takashi
First Department of Internal Medicine Osaka City University Medical School
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