Circulating Levels of Soluble Fas Ligand in Cachexic Patients with COPD are higher than those in Non-Cachexic Patients with COPD
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概要
- 論文の詳細を見る
Objective Apoptosis may be involved in the pathophysiology of cachexia in patients with chronic obstructive pulmonary disease (COPD). The purpose of this study is to assess the potential role of the Fas-Fas ligand (FasL) system in cachexic patients with COPD.Patients and Methods We measured the circulating levels of soluble FasL (sFasL), with a newly developed, highly sensitive enzyme-linked immunosorbent assay system in seventy patients with COPD and forty-seven control subjects.Results The levels of sFasL in the COPD patients were significantly lower than those in the control subjects (46±29 vs. 55±28 pg/ml; p<0.05), whereas the levels of soluble Fas (sFas) remained unchanged between the two groups. The significant correlation between the levels of sFasL and sFas, observed in the control subjects (r=0.304; p<0.05), was absent in the COPD patients. Cachexic COPD patients with a relatively lower BMI (BMI <20 kg/m2, n=45) and %fat (%fat <20%, n=34), showed significantly increased levels of sFasL compared to non-cachexic COPD patients with a relatively higher BMI (BMI ≥20 kg/m2, n=25) and %fat (%fat ≥20%, n=36) (BMI; 51±33 vs. 36±15 pg/ml; p<0.05. %fat; 55±33 vs. 37±21 pg/ml; p<0.01), due to the inverse relationships between the body composition measurements and the levels of sFasL observed exclusively in the patients (BMI; r=-0.307; p<0.05. %fat; r=-0.283; p<0.05).Conclusion These results may suggest that the Fas-FasL system does not play a significant role in the potential triggers of enhanced apoptosis leading to skeletal muscle wasting and adipose tissue depletion in cachexic patients with COPD.
- 社団法人 日本内科学会の論文
- 2005-11-01
著者
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Takabatake Noriaki
First Department of Internal Medicine Yamagata University School of Medicine
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Kubota Isao
First Department of Internal Medicine Yamagata University School of Medicine
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Kubota Isao
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Abe Shuichi
First Department of Internal Medicine, Yamagata University School of Medicine
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Takabatake Noriaki
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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Takabatake Noriaki
山形大学 医学部循環･呼吸･腎臓内科学
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Takabatake Noriaki
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Noriaki Takabatake
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Abe Shuichi
First Department Of Internal Medicine Yamagata University School Of Medicine
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Inoue Sumito
First Department Of Internal Medicine Yamagata University School Of Medicine
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Shibata Yoko
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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ARAO Tsuyoshi
First Department of Internal Medicine, Yamagata University School of Medicine
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SATA Makoto
First Department of Internal Medicine, Yamagata University School of Medicine
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SHIBATA Yoko
First Department of Internal Medicine, Yamagata University School of Medicine
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Sata Makoto
First Department Of Internal Medicine Yamagata University School Of Medicine
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Arao Tsuyoshi
First Department Of Internal Medicine Yamagata University School Of Medicine
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Kubota Isao
Department Of Cardiology Pulmonology And Nephrology Yamagata University Of School Of Medicine
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Shibata Yoko
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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