Serum Resistin is Associated With High Risk in Patients With Congestive Heart Failure : A Novel Link Between Metabolic Signals and Heart Failure

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概要

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• Background Resistin is derived from fat tissue in rodents, and serum levels are elevated in animal models of obesity and insulin resistance. Recent studies have reported that resistin is correlated with markers of inflammation and oxidative stress and is predictive of coronary atherosclerosis in humans. However, clinical significance of serum resistin has not been examined in heart failure. Therefore, the purpose of this study was to examine whether: (1) resistin is correlated with the severity of heart failure; and (2) resistin can predict clinical outcomes of patients with heart failure. Methods and Results Serum levels of resistin in 126 patients hospitalized for heart failure and 18 control subjects were measured. The patients were followed up with end-points of cardiac death and re-hospitalization caused by worsening of heart failure. The serum resistin level was higher in patients with heart failure than in control subjects and increased with advancing New York Heart Association functional class. The normal upper limit of the resistin level was determined as the mean +2standard deviation value of control subjects (14.1ng/ml). In heart failure patients, the cardiac event rate was higher in patients with a high resistin level than in those with a normal level. Among age, body mass index, serum levels of resistin, brain natriuretic peptide, loop diuretics selected by the univariate Cox regression hazard analysis, age and resistin were significant predictors of future cardiac events by multivariate Cox analysis. Conclusion Serum resistin was related to the severity of heart failure and associated with a high risk for adverse cardiac events in patients with heart failure.

• 社団法人日本循環器学会の論文
• 2007-03-20

著者

• TAKEISHI Yasuchika

  Department of Cardiology and Hematology, Fukushima Medical University

• KUBOTA Isao

  Department of Cardiology, Pulmonology and Nephrology, Yamagata University of School of Medicine

• Watanabe Tetsu

  Department of Cardiology, Pulmonology, and Nephrology

• Nozaki Naoki

  Department of Cardiology, Pulmonology, and Nephrology

• Arimoto Takanori

  First Department of Internal Medicine Yamagata University School of Medicine

• Takabatake Noriaki

  First Department of Internal Medicine Yamagata University School of Medicine

• Hirono Osamu

  Department of Cardiology, Pulmonology and Nephrology, Course of Internal Medicine and Therapeutics,

• Niizeki Takeshi

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Arimoto Takanori

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Hirono O

  Department Of Cardiology Yamagata Prefectural Shinjo Hospital

• Hirono Osamu

  山形大学 循環･呼吸･腎臓内科

• Osamu Hirono

  山形大学 1内

• Hirono Osamu

  山形大学 医学部第1内科

• Kubota Isao

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Niizeki Takeshi

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Niizeki Takeshi

  山形大学 医学部循環･呼吸･腎臓内科学

• Niizeki Takeshi

  First Department Of Internal Medicine And Division Of Radiology Yamagata University School Of Medici

• Nozaki Naoki

  Depertment Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Nozaki Naoki

  山形大学 循環･呼吸･腎臓内科

• Nozaki Naoki

  Department Of Applied Chemistry Tokyo University Of Agriculture And Technology

• Tsunoda Yuichi

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Tsunoda Yuichi

  山形大学 循環器内科

• Tsunoda Yuichi

  山形大学 医学部第1内科

• Watanabe Tetsu

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Arimoto T

  Department Of Cardiology Pulmonary And Nephrology Yamagata University School Of Medicine

• Arimoto Takanori

  筑波大学 人間総合科学研究科循環器内科

• Arimoto Takanori

  Departments Of Cardiology Ishinomaki Red Cross Hospital

• Nitobe Joji

  Department of Cardiorogy, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Takabatake Noriaki

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Nitobe Joji

  山形大学 医学部循環･呼吸･腎臓内科学

• Nitobe Joji

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Nitobe Joji

  First Department Of Internal Medicine Yamagata University School Of Medicine

• Takabatake Noriaki

  山形大学 医学部循環･呼吸･腎臓内科学

• Takabatake Noriaki

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Noriaki Takabatake

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Takeishi Yasuchika

  Department Of Cardiology And Hematology Fukushima Medical University

• Araki Takao

  Department Of Cardiology Pulmonary And Nephrology Yamagata University School Of Medicine

• Arimoto Takanori

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Hirono Osamu

  Department Of Cardiology Yamagata Prefectural Shinjo Hospital

• Takeishi Yasuchika

  Department Of Cardiology And Hematology Fukushima Medical School

• Arimoto Takanori

  Division Of Cardiology Ishinomaki Red Cross Hospital

• Kubota Isao

  Department Of Cardiology Pulmonology And Nephrology Yamagata University Of School Of Medicine

• Watanabe Tetsu

  Department Of Basic Clinical Science And Public Health Tokai University School Of Medicine

• Takeishi Yasuchika

  Department Of Advanced Cardiac Therapeutics Fukushima Medical University

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