Short Cardiac Iodine-123-Metaiodobenzylguanidine Imaging Protocol in Heart Failure

概要

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Background For assessment of cardiac sympathetic nervous activity, the conventional protocol for iodine-123-metaiodobenzylguanidine (^<123>I-MIBG) imaging requires several hours. Methods and Results To establish whether it is possible to shorten the conventional ^<123>I-MIBG imaging protocol, anterior planar imaging was performed in 42 heart failure (HF) patients at 5, 15 and 180min. The washout rate of ^<123>I-MIBG from 5 to 15min (WR5-15min) was calculated as a novel index. WR5-15min closely correlated with the conventional washout rate and inversely correlated with the heart to mediastinum ratio. Univariate Cox analysis revealed that rapid WR5-15min, augmented plasma B-type natriuretic peptide level, and decreased left ventricular ejection fraction (LVEF) were predictors for cardiac events. Multivariate analysis showed WR5-15min and LVEF were independent predictors. The cardiac event rate was markedly higher (73%) in patients when both WR5-15min and LVEF were abnormal. Conclusions WR5-15 min obtained from anterior planar imaging is useful for evaluating the severity of HF and clinical outcome, and may shorten the cardiac ^<123>I-MIBG scintigraphy protocol.
社団法人日本循環器学会の論文
2008-06-20