Direct Effects of Class I Antiarrhythmic Drugs on Epicardial Electrograms in Dogs
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概要
- 論文の詳細を見る
The effects of class I antiarrhythmic drugs on epicardial electrograms during regular atrial pacing were investigated in anesthetized, open-chest dogs. Lidocaine, flecainide or disopyramide was infused selectively into the distal site of the left anterior descending artery. Lidocaine produced a dose-dependent elevation of ST segment without changing the amplitude of R wave. Flecainide produced a dose-dependent increase of R-wave amplitude accompanied by the augmentation of negative T. The ST segment was elevated at the high dose. The QRST area did not change at the low dose but significantly increased at the high dose, indicating that the ST-T change at the low dose was secondary to changes in ventricular depolarization. The effects of disopyramide on R wave and ST segment were between those of lidocaine and flecainide. The major action of lidocaine was the acceleration of ventricular repolarization while that of flecainide was the deceleration of ventricular conduction. Disopyramide had an action that was intermediate between the two drugs.
- Japanese Heart Journal Associationの論文
著者
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Kubota Isao
First Department of Internal Medicine Yamagata University School of Medicine
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Tachibana Hidetada
First Department of Internal Medicine, Yamagata University
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Yamaki Michiyasu
山形大学 循環呼吸腎臓内科学
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Tachibana Hidetada
First Department Of Internal Medicine Yamagata University School Of Medicine
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WATANABE Testu
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
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YAMAKI Michiyasu
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
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TOMOIKE Hitonobu
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
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Tomoike Hitonobu
First Department Of Internal Medicine Yamagata University Medical School
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YAMAKI Michiyasu
First Department of Internal Medicine, Yamagata University School of Medicine
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TACHIBANA Hidetada
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
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