Anisotropic Effects of Sodium Channel Blockers on the Wavelength for Ventricular Excitation in Dogs

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概要

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• The purpose of this study was to determine the anisotropic effects of sodium channel blockers on wavelength (WL) and proarrhythmia. In 18 anesthetized, open chest dogs, a 64-electrode array was placed on the left ventricle and the ventricle was constantly paced. Disopyramide, lidocaine or flecainide was intracoronarily administered. Conduction velocity (θ) and activation-recovery interval (ARI) were measured in the longitudinal (L) and transverse (T) directions. Flecainide markedly decreased θL, but did not alter θT or ARIs in either direction. As a result, the wavelength was significantly shortened only in the L direction. Disopyramide or lidocaine did not show direction-dependent effects on θ or WL. In 3 of 6 dogs with flecainide exposure, ventricular fibrillation (VF) developed. However, no VF occurred with disopyramide or lidocaine. Accordingly, the WL is dependent on the fiber orientation of myocardium. The anisotropic shortening of the WL may explain the character of the proarrhythmia observed with flecainide.

• 社団法人日本循環器学会の論文
• 2000-08-20

著者

• Yamaguchi Seiji

  Internal Medicine Sagae Hospital

• Tomoike Hitonobu

  National Cardiovascular Center

• Yamaki Michiyasu

  Takaha Public Hospital

• Kubota Isao

  First Department of Internal Medicine Yamagata University School of Medicine

• Tachibana Hidetada

  First Department of Internal Medicine, Yamagata University

• Watanabe Tetsu

  First Department of Internal Medicine, Yamagata University School of Medicine

• Yamaki Michiyasu

  Disivion Of Medical Informatics Yamagata University School Of Medicine

• Tachibana Hidetada

  山形大学 循環・呼吸・腎臓内科学

• Tachibana H

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Tachibana Hidetada

  First Department Of Internal Medicine Yamagata University School Of Medicine

• YAMAKI Michiyasu

  First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan

• TOMOIKE Hitonobu

  First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan

• Yamauchi Sou

  First Department of Internal Medicine, Yamagata University School of Medicine

• Yamauchi Sou

  The First Department Of Internal Medicine Yamagata University School Of Medicine

• Yasui S

  The Department Of Public Health

• Tomoike Hitonobu

  First Department Of Internal Medicine Yamagata University School Of Medicine

• Yamauchi Sou

  First Department Of Internal Medicine Yamagata University School Of Medicine

• Tomoike Hitonobu

  First Department Of Internal Medicine Yamagata University Medical School

• Yasui Shoji

  First Department Of Internal Medicine Yamagata University School Of Medicine

• Yasumura Seiji

  Nagoya National Hospital

• YAMAKI Michiyasu

  First Department of Internal Medicine, Yamagata University School of Medicine

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