Role of Nitric Oxide in the Progression of Cardiovascular Remodeling Induced by Carotid Arterio-Venous Shunt in Rabbits
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概要
- 論文の詳細を見る
Despite a variety of biological roles for nitric oxide (NO) in the cardiovascular system, little is known about whether NO is involved in cardiac hypertrophy. We hypothesized that NO production following a sustained increase in shear stress by volume-overload modifies the level of cardiac hypertrophy independent of hemodynamic changes. Volume-overload was induced by shunt formation between the left common carotid artery and the external jugular vein in 21 rabbits. These shunt rabbits were randomly assigned to 3 groups: shunt with no treatment (n=8), shunt treated with a low dose of NG-nitro-L-arginine methyl ester (L-NAME, 0.5 g/L in drinking water, n=8), and shunt with a high dose of L-NAME (1.5 g/L, n=5). Eight sham operated rabbits were used as controls. Treatments were started immediately after operation and were continued for 6 weeks. Chronic volume-overload by shunt formation caused left ventricular dilatation and arterial enlargement proximal to the fistula. The relative wall thickness of the left ventricle was decreased, indicating eccentric cardiac hypertrophy. L-NAME elevated mean arterial blood pressure (P<0.01) and reduced the increment of cardiac output (P<0.05). L-NAME attenuated ventricular weight (P<0.01), ventricular cavity dilatation (P<0.01), and arterial enlargement (P<0.05). The re-capitulation of atrial natriuretic factor mRNA in the hypertrophied left ventricular myocardium by volume-overload was attenuated with L-NAME. In this model with chronic volume-overload, NO plays a pivotal role in the progression of cardiovascular remodeling by regulating the loading conditions of the heart.
- Japanese Heart Journal Associationの論文
著者
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Tomoike Hitonobu
National Cardiovascular Center
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Takeishi Yasuchika
The First Department of Internal Medicine, Yamagata University School of Medicine
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Miyamoto Takuya
The First Department of Internal Medicine, Yamagata University School of Medicine
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Shishido Tetsurou
The First Department of Internal Medicine, Yamagata University School of Medicine
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Takeishi Yasuchika
The First Department Of Internal Medicine Yamagata University School Of Medicine
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ITOH MAKOTO
The First Department of Internal Medicine, Nagoya City University Medical School
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Takahashi Hiroki
The First Department of Internal Medicine, Sapporo Medical University School of Medicine
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Kubota Isao
the First Department of Internal Medicine, Yamagata University School of Medicine
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Kubota Isao
The Fiest Department Of Internal Medicene Yamagata University School Of Medicine
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Itoh Makoto
The Faculty Of Engineering Nagasaki University
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