MATHEMATICAL EVALUATION OF 24-HOUR BLOOD-PRESSURE VARIABILITY IN YOUNG, MIDDLE-AGED AND ELDERLY HYPERTENSIVE PATIENTS

概要

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The characteristics of 24-hour blood pressure variation in hypertensive patients were assessed using new indices of variability. Blood pressure of 43 inpatients with essential hypertension was measured using a portable device without disturbing daily behaviors. Variances in systolic and diastolic pressure values obtained for a day (SD_d^2), and short-term (SD_h^2) and long-term (SD_<24>^2) variances were calculated; their relationship was expressed as SD_d^2 =SD_h^2 + SD_<24>^2. SD_h and SD_<24> were expedient in assessing the relatively fast and slow blood-pressure variations, respectively. The results showed that the ratio SD_h^2/SD_d^2 (percentile of the short-term variance in a whole-day variance) increased and therefore SD_<24>^2/SD_d^2 decreased as age increased for both systolic and diastolic pressures. It was found, moreover, that systolic SD_h was significantly related to age and baroreflex sensitivity, and systolic SD_<24> to the heart rate during waking hours. The physiological and clinical significance of SD_h and SD_<24> is discussed, briefly, including arterial wall stiffness.
社団法人日本循環器学会の論文
1987-10-20