SERUM CONCENTRATION AND EFFECTS OF A SINGLE DOSE OF ENALAPRIL MALEATE IN PATIENTS WITH ESSENTIAL HYPERTENSHION
スポンサーリンク
概要
- 論文の詳細を見る
The antihypertensive effect of a non-sulfhydryl, long acting ACE (angiotensin converting enzyme) inhibitor, MK-421, was evaluated by administering a single does of 10 mg to 13 patients with mild to moderate essential hypertension. The pharmacokinetic profile of MK-421 and its potent active metabolite, MK-422, was also assessed, together with the effect on the various components of the renin-angiotensin system. A single does of MK-421 produced a significant fall in MBP from 2 to 24 hours post-drug. As could be expected, plasma ACE activity was suppressed up to 24 hours after MK-421. The half-like of MK-422, Cmax and [AUC]^<24>_0 of MK-421 and MK-422 were measured. No significant change in plasma bradykinin or urinary excretion rate of kallikrein was observed, whereas a slight increase was observed in the urinary excretion rate of kinins after MK-421 in 8 patients. Significant correlations were observed between pretreatment PRA levels and the maximum fall in MBP.
- 社団法人日本循環器学会の論文
- 1985-01-20
著者
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Takagi Nobuyoshi
The Second Department Of Internal Medicine Yokohama City University
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Takagi Nobuyoshi
横浜市立大学 第2内科
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Kaneko Yoshihiro
Second Department Of Internal Medicine Yokohama City University Hospital
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Kaneko Yoshihiro
Department Of Internal Medicine Jikei University School Of Medicine
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MIYAZAKI NAOMICHI
Second Department of Internal Medicine, Yokohama City University, School of Medicine
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MIYAZAKI NAOMICHI
The Second Department of Internal Medicine,School of Medicine,Yokohama City University
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KANEKO YOSHIHIRO
The Second Department of Internal Medicine,School of Medicine,Yokohama City University
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Goto Eiji
2nd Dept. Of Int. Med. Yokohama City University School Of Medicine
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Yasuda G
Yokohama City Univ. School Of Medicine Yokohama Jpn
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SHIONOIRI HIROSHI
The Second Department of Internal Medicine, Yokohama City University
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GOTOH EIJI
The Second Department of Internal Medicine, Yokohama City University
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YASUDA GEN
The Second Department of Internal Medicine, Yokohama City University
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UNEDA SUSUMU
The Second Department of Internal Medicine, Yokohama City University
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Kaneko Yoshihiro
The Second Department Of Internal Medicine Yokohama City University
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Miyazaki Naomichi
Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Goto Eiji
Intern. Med. Of Yokohama City University
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Gotoh Eiji
The Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Gotoh Eiji
Intern. Med. of Yokohama City University
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Sionoiri Hiroshi
2nd Department Of Internal Medicine Yokohama City University
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Kaneko Yoshihiro
The Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Shionoiri Hiroshi
The Second Department Of Internal Medicine Yokohama City University School Of Medicine Yokohama Japa
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Yasuda Gen
The Second Department Of Internal Medicine Yokohama City University
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Uneda Susumu
The Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Uneda Susumu
The Second Department Of Internal Medicine Yokohama City University
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Shionoiri Hiroshi
Second Department Of Internal Medicine Yokohama City University Hospital
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Shionoiri Hiroshi
2nd Department Of Internal Medicine Yokohama City University
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Miyazaki Naomichi
The Second Department Of Internal Medicine Yokohama City University
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Yoshihiro Kanako
Second Department Of Internal Medicine Yokohama City University Hospital
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Shionoiri Hiroshi
Graduate School Of Science And Technology Niigata University
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Shionoiri Hiroshi
The Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Gotoh Eiji
The Second Department Of Internal Medicine Yokohama City University
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