Experimental Study of the Effects of Multi-site Sequential Ventricular Pacing on the Prophylaxis of Ventricular Fibrillation
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概要
- 論文の詳細を見る
Previous studies report a significant prophylactic effect on the occurrence of atrial fibrillation by simultaneous multi-site atrial pacing. We investigated the effects of multi-site sequential ventricular pacing (MSVP), which may be preferable to simultaneous multi-site pacing in terms of the prophylaxis of the occurrence of ventricular fibrillation (VF). Needle electrodes were inserted at ten different epicardial sites on both ventricles for MSVP in 12 adult beagle dogs. Four premature ventricular extrastimuli (PVE) were introduced to provoke VF reproducibly from a separate electrode in the left ventricle. The 4 PVE were applied to try to provoke VF during MSVP in a comparable fashion to the activation sequence during sinus rhythm. We compared the prophylactic effects of MSVP on the inducibility of VF by changing the number of stimulation sites to either 1, 3, 5, or 10 epicardial sites. We performed a total of 363 trials of induction and suppression of VF. The occurrence rates of VF by the 4 PVE for the various number of epicardial stimulation sites of MSVP, i.e., at 1, 3, 5, and 10 sites, were 0.8263, 0.4286, 0.4450, and 0.2857, respectively (p0.05). There was a significant prophylactic effect of MSVP on the inducibility of VF, and this effect became stronger as the number of MSVP sites was increased from 3 to 10. The hemodynamic state was relatively stable during MSVP. MSVP seems to be a promising method with which to reduce the occurrence of VF, and a larger number of stimulation sites would be more effective in terms of the prophylaxis of VF. (Jpn Heart J 2000; 41: 193-204)
- Japanese Heart Journal Associationの論文
著者
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Okishige Kaoru
Cardiac Electrophysiology Laboratory Cardiovascular Department Yokohama Red Cross Hospital
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Hiejima Kazumasa
School of Allied Health Sciences, Faculty of Medicine, Tokyo Medical and Dental University
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Hiejima Kazumasa
東京医科歯科大学 第1内科
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OHKUBO Toyoyuki
Second Department of Internal Medicine, Tokyo, Japan.
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GOSEKI Yoshinari
Second Department of Internal Medicine, Tokyo, Japan.
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MATSUBARA Tetsu
Second Department of Internal Medicine, Tokyo, Japan.
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IBUKIYAMA Chiharu
Second Department of Internal Medicine, Tokyo, Japan.
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Ibukiyama Chiharu
横浜赤十字病院
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Ibukiyama Chiharu
Second Department Of Internal Medicine Tokyo Medical College
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Hiejima Kazumasa
School Of Allied Health Science Tokyo Medical And Dental University
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MATSUBARA Tetsu
Second Department of Internal Medicine, Tokyo Medical College, School of Medicine
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GOSEKI Yoshinari
Second Department of Internal Medicine, Tokyo Medical College, School of Medicine
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OKISHIGE Kaoru
Cardiovascular Department, Yokohama Red Cross Hospital, Yokohama, Japan.
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OHKUBO Toyoyuki
Second Department of Internal Medicine, Tokyo Medical College, School of Medicine
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