Extracellular Matrix in Diabetic Vascular Wall : Implication in Accelerated Atherogenicity

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概要

• 論文の詳細を見る

• Diabetes mellitus is a known accelerating factor for atherosclerotic vascular diseases. The cause of highly proliferative property in diabetic vascular smooth muscle cells(SMC)includes overexpression of the platelet-derived growth factor(PDGF)β-receptor. Fibronectin, an extracellular matrix protein, significantly activated the PDGF β-receptor promoter in cultured rat SMC. The fibronectin-induced transcriptional activation was dependent on activity of focal adhesion kinase and MEK1 / ERK pathway. Introduction of a dominant negative mutant receptor for TGF-β into balloon-injured rat carotid artery inhibited expression of PDGF β-receptor as well as fibronectin in the arterial wall. Moreover, growth and migratory signals by PDGF were synergistically enhanced by an extracellular matrix protein osteopontin(OPN). Exposure of SMC to high glucose enhanced OPN secretion via hexosamine / protein kinase C pathways. The alteration of SMC phenotype characterized by modified expression of extracellular matrix components seems to be an important determinant of atherogenicity in diabetes.

• 日本結合組織学会の論文
• 1999-09-25

著者

• SAITO Yasushi

  Second Department of Internal Medicine, School of Medicine, Chiba University

• Tamura Ken

  Second Department Of Internal Medicine Tokyo Medical University

• Yokote Koutaro

  Second Department Of Internal Medicine Chiba University Hospital

• MORI Seijiro

  Tokyo Metropolitan Geriatric Hospital

• Takemoto Minoru

  Second Department Of Internal Medicine Chiba University School Of Medicine

• Tamura Ken

  Second Department Of Internal Medicine Chiba University School Of Medicine

• MORI Seijiro

  Second Department of Internal Medicine, Chiba University School of Medicine

• Saito Yasushi

  Second Department Of Internal Medicine School Of Medicine Chiba University

• Saito Yasushi

  Department Of Clinical Cell Biology

• Mori Seijiro

  Department Of Clinical Cell Biology

• Mori Seijiro

  Second Department Of Internal Medicine School Of Medicine Chiba University

• Mori Seijiro

  東京都健康長寿医療センター 内科

• Saito Yasushi

  Second Department Of Internal Medicine Chiba University School Of Medicine

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