AGE-RELATED IMMUNOHISTOPATHOLOGICAL CHANGES OF MURINE LUPUS NEPHRITIS IN NZB/NZW F_1 MICE USING SERIAL RENAL BIOPSY

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Serial renal biopsies were performed to examine the age-related morphological changes of murine lupus nephritis in NZW/NZB (NZB/W) F_1 mice. Renal biopsies were performed at 3, 5, 7 and 9 months of age in the same mouse. The earliest histological change was slight mesangial thickening. Mesangial hypercellularity was seen in one-third of all the cases at 7 months. With age, the incidence of mesangial thickening was progressively increased, and capillary wall thickening appeared simultaneously. The incidence of interstitial cell infiltration was found in 100% at 11 months. Significant correlations among the capillary wall thickening, crescent formation and proteinuria were observed. In an immunofluorescent study, a significant correlation between immunofluorescent deposition in the capillary wall and proteinuria was observed. The pattern of immunoglobulin deposition changed from mesangial type to capillary type with age. However, the pattern of gp 70 (retroviral antigen) deposition in glomeruli varied considerably, and in some mice the gp 70 deposition decreased with age. Furthermore, a significant correlation between the titer of circulating gp 70 immune complex (IC) and gp 70 deposits in glomeruli was found. These results suggest that the age-related morpholigical changes are due to multifarious characters of IC and due to numerous immunological disorders.
日本組織細胞化学会の論文