Interaction between Dietary Calcium and Sodium in Stroke-prone SHR (SHRSP)
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概要
- 論文の詳細を見る
Na loading accelerates urinary Ca excretion and this calciuretic effect of Na is possibly related to the aggravation of hypertension by Na loading in SHRSP. Our observation on Na-loaded SHRSP, so far indicated bones were more fragile, so that excess Na intake might be pathogenically involved in the development of osteoporosis. Therefore, Na-loaded SHRSP could be a good model for osteoporosis. On the other hand, Ca supplementation attenuated the development of severe hypertension and stroke in SHRSP. Since urinary Na excretion was increased in the group given the Casupplemented diet, the beneficial effect of Ca appeared to be ascribed to the acceleration of urinary Na excretion. Thus, it can be concluded under excess Na intake, enough Ca intake is important for the prevention not only of hypertensive diseases but also of osteoporosis.
- International Heart Journal刊行会の論文
著者
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Nara Yasuo
Department Of Nutrition Science Division Of Applied Life Sciences Graduate School Of Integrated Scie
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Horie Ryoichi
Department Of Hematology Faculty Of Medicine Kitasato University
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Ikeda Katsumi
Department Of Breast Surgical Oncology Osaka City General Hospital
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Tsuchikura Satoru
Department of Pathology, Shimane Medical University
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Eguchi Tetsuya
Department of Pathology, Shimane Medical University
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Yamori Yukio
Department of Life Science, Graduate School of Human and Environmental, Kyoto University
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