Studies on Stroke in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP):(I) Local Factor Analysis on Stroke

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The precise predilection sites of stroke in nearly 1, 000 cases of stroke-prone SHR (SHRSP) were morphologically studied and statistical analysis showed that the first and second predilection sites were the cortical region and basal ganglia. Our microangiographical studies on these predilection sites and comparative analysis on the angioarchitecture of these regions between rats and man threw light on the pathogenetic importance of "recurrent branchings" which were noted in the cortical region in rats as well as in the basal ganglia of both rat and human brains. Two other angioarchitectural characteristics common to these predilection sites both in rat and man were confirmed to be "hypovascularity" and "boundary zone". Our present findings substantiated the view that these 3 angioarchitectural "minor loci" and the cerebral circulatory disturbance subsequently caused by these organic weak points were the main local factors of stroke common in the rat and human brains.Now that the cortical lesions characteristic in SHRSP are supposed to be caused by the same mechanism as the most frequent lesions of the basal ganglia in man, SHRSP can be regarded as a good pathogenetic model for the studies on stroke in man.
International Heart Journal刊行会の論文