Electronmicroscopic autoradiographic study of the distribution of 3H-diltiazem in myocardial cells.
スポンサーリンク
概要
- 論文の詳細を見る
The distribution of 3H-diltiazem in myocardial cell organelles was studied using an electronmicroscopic autoradiographic technique. At 3, 5 and 10min after 3H-diltiazem injection, silver grains, which indicate the existence of diltiazem, were detected in plasma membranes and intracellular organelles. Silver grains in Tsystems were observed more frequently at 3min than at 5 and 10min. In contrast, silver grains in sarcoplasmic reticula and mitochondria apparently increased with the passage of time. These findings suggest that diltiazem is transported through the T system and may accumulate within the sarcoplasmic reticula and mitochondria. Furthermore, our study revealed morphologically for the first time that the intracellular sites of action where diltiazem was directed were possibily the mitochondria.
- International Heart Journal刊行会の論文
著者
-
Tagami Motoki
Department Of Internal Medicine Sanraku Hospital
-
Kubota Akiyoshi
Department Of Internal Medicine (2) Sanraku Hospltal
-
Nara Yasuo
Department Of Nutrition Science Division Of Applied Life Sciences Graduate School Of Integrated Scie
-
Horie Ryoichi
Department Of Hematology Faculty Of Medicine Kitasato University
-
Maezawa Hidenori
Third Department Of Internal Medicine Tokyo Medical And Dental University
-
SUNAGA Toshiaki
Department of Clinical Physiology and Medicine, Tokyo Medical and Dental University, School of Medicine
-
Yamori Yukio
Department of Life Science, Graduate School of Human and Environmental, Kyoto University
-
HORIE Ryoichi
Department of and Neurosurgery, Kyoto University
-
Nara Yasuo
Department of Medicine, SANRAKU Hospital
関連論文
- Immunocytochemical Analysis of the AtheroscLerotic lesion : 54th Annual Scientific Session of the Japanese Circulation Society
- Immunocytochemical analysis of the site of percutaneous transluminal coronary angioplasty (PTCA).
- The Role of Cytochrome P-450 in Salt-Sensitive Stroke in Stroke-Prone Spontaneously Hypertensive Rats
- Assessment of in vivo Oxidative Stress in Hypertensive Rats and Hypertensive Subjects in Tanzania, Africa
- Genetic Vulnerability of Cortical Neurons Isolated from Stroke-Prone Spontaneously Hypertensive Rats in Hypoxia and Oxygen Reperfusion
- Training in Swimming Reduces Blood Pressure and Increases Muscle Glucose Transport Activity as Well as GLUT4 Contents in Stroke-Prone Spontaneously Hypertensive Rats
- 4) HISTOPATHOLOGICAL INVESTIGATION OF VARIOUS ORGANS IN MYOCARDIAL ISCHEMIC RATS (MIR)
- 1)NOREPINEPHRINE-INDUCED HYPERTROPHY OF CULTURED MYOCYTES : THE 7th CONFERENCE ON CARDIOMYOPATHY
- P-18-A Detailed examination during cartilage formation by human mesenchymal stem cells in a three-dimentional culture : alginate bead culture and pellet culture(THE JOINT MEETING OF THE 44TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCH
- Amlodipine and Carvedilol Prevent Cytotoxicity in Cortical Neurons Isolated from Stroke-Prone Spontaneously Hypertensive Rats
- -280-ULTRASTRUCTURE AND FUNCTION OF THE HEART IN MYOCARDIAL ISCHEMIC RATS (MIR) : SPONTANEOUSLY DEVELOPING ISCHEMIC HEART DISEASE : Ischemic Heart Disease II : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRC
- -170-Na^+-H^+ EXCHANGE ACTIVITY AND CYTOPLASMIC pH IN CULTURED VASCULAR SMOOTH MUSCLE CELLS FROM STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS : Cardiac Metabolism, Cardiac Biochemistry : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC M
- -85-EFFECTS OF CHRONIC TREADMILL EXERCISE ON HEMODYNAMIC IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS
- A Smooth Muscle Cell Specific Monoclonal Antibody in the Immunocytochemical Analysis of Atherosclerotic Lesions
- Preventive Effects of Shinchimotsu-koka-to on Renal Lesions in Stroke-Prone Spontaneously Hypertensive Rats
- GLUCOSE TOLERANCE IN SPONTANEOUSLY HYPERTENSIVE RATS
- Morphological Analysis of the Pathogenesis of Hypertensive Cerebrovascular Lesions: Role of Monocytes and Platelets in Intracerebral Vessel Occlusions : THE 17th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS AS A MODEL FOR TOXEMIA OF PREGNANCY AND AGGRAVATING AND PREVENTIVE EFFECTS OF MATERNAL MODIFICATIONS DURING PREGNANCY ON OFFSPRING'S GROWTH : The 53th Annual Scientific Session of the Japanese Circulation Socie
- Experimental and Clinical Studies on the Relationship between Genetic Hypertension and Glucose Metabolism
- Transient inhibition of NF-κB by DHMEQ induces cell death of primary effusion lymphoma without HHV-8 reactivation
- Further Vectorcardiographical and Pathotopographical Studies on the Heart of Spontaneously Hypertensive Rats (SHR)
- VECTORCARDIOGRAPHIC STUDY ON LEFT VENTRICULAR HYPERTROPHY IN SPONTANEOUSLY HYPERTENSIVE RATS
- Application of Hydrogenated Amorphous-Silicon to Bipolar Transistors
- Pathogenesis of Acute Arterial Fat Deposition in Spontaneously Hypertensive Rats
- Experimental Studies on the Pathogenesis and Prophylaxis of Stroke in Stroke-prone Spontaneously Hypertensive Rats (SHR) : (2) Prophylactic Effect of Moderate Control of Blood Pressure on Stroke
- A-43. Clinical and Endocrinological Evaluations of Acromegaly : Comparison with Cryogenic and Microsurgical Treatments
- Application of Amorphous-Silicon Field-Effect Transistors in Three-Dimensional Integrated Circuits
- Effect of Ascorbic Acid on the Development of Stroke in Stroke-Prone SHR
- Sex Difference in Cerebrovascular Atherogenesis in Rats-A Preliminaly Report
- Prophylactic Trials for Stroke in Stroke-Prone SHR : Effect of Sex Hormones
- Experimental Studies on Sex Difference in Stroke-Prone SHR (SHRSP) : Hypoxic Vulnerability and Aortic Brittleness
- Detection of Biomembrane Abnormalities of Erythrocytes from Stroke-Prone SHR (SHRSP) before the Development of Hypertension by the Method of Tetraphenyl-Phosphonium Electrode and Its Preliminary Application to Men
- EPIDEMIOLOGICAL ANALYSIS ON THE MECHANISM OF CIGARETTE SMOKING AS A RISK FACTOR IN CARDIOVASCULAR DISEASES
- Cerebral Circulation and the Initiation Mechanism of Stroke in Stroke-prone Spontaneously Hypertensive Rats (SHRSP)
- Relation between Changes in Optic Fundi and the Development of Cardiovascular Diseases:a Preliminary Report (1)
- Relation between Changes in Optic Fundi and the Development of Cardiovascular Diseases:a Preliminary Report (2)
- EFFECT OF SMOKING ON CHOLESTEROL METABOLISM IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR)
- Effect of High Protein Diet on Cerebral Blood Flow and Cerebrovascular Reactivity in Rats
- Cellular Mechanisms of Cardiovascular Hypertrophy in Spontaneously Hypertensive Rats (SHR) and Their Modification
- Effect of Radiation on the Heart in SHRSP:stroke-prone spontaneously hypertensive rats
- Effect on Na+, K+ ATPase Activity of Erythrocytes after Acute and Chronic Salt Loading in Normotensive WKY Rats
- Prophylactic Trials for Stroke in Stroke-Prone SHR (7):Effect of Various Lipid-Rich Diets on Hypertension, Lipoprotein-Profiles and Fatty Metamorphosis of the Liver
- Effect of Salt Loading on Fatty Acid Composition in Various Organs of Stroke-Prone SHR (SHRSP)
- Relationship between Intracellular Free Ca2+, Mg2+ and Blood Pressure in Prehypertensive and Hypertensive SHRSP and age-mutched WKY
- Analysis on the Vectorcardiographical Pattern of SHR at Various Ages
- Brain metabolism under bilateral arteries ligatation of stroke-prone spontaneously hypertensive rats studied with 31P-NMR
- Synaptosomal Membrane Characteristics in Stroke-prone SHR (SHRSP), Stroke-resistant SHR (SHRSR) and Wistar-Kyoto Rats (WKY)
- Effect of Long-term Salt-loading on Heart Weight in Rats
- Biochemical Aspect of Salt Induced Left Ventricular Hypertrophy in Rats
- Lipid accumulation in cultured vascular smooth muscle cells (VSMC) from the aorta of strokeprone SHR (SHRSP) under hypoxic condition
- Effect of Sodium or Potassium Loading on Reactive Hypercholesterolemia in Rats
- Effects of Maternal Administration of KCl and Hydralazine on Their Offspring's Growth
- Effect of Various Fatty Acids on Proliferation of Cultured Smooth Muscle Cells (SMC) from the Aorta of Stroke-Prone SHR (SHRSP)
- Comparison of Na+-H+ Exchange Activity in Cultured Vascular Smooth Muscle Cells between Stroke-Prone SHR and WKY
- Effect of NaCl on Cerebral Stroke and Cerebrovascular Atherogenesis in Rats
- Studies on Stroke in Stroke-Prone Spontaneously Hypertensive Rat (SHRSP):(II) Cerebrovascular Fat Deposition and Cerebrovascular Permeability
- Studies on Stroke in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP):(I) Local Factor Analysis on Stroke
- Experimental Studies on Atherogenesis:(I) Acute Arterial Fat Deposition in Various Hypertensive Rats
- The Study of Mevalonic Acid Metabolites in Spontanously Hypertensive and Normotensive Rat
- Quantitative Observations of Fine Structure of Myocardial Plasma Membrane in Rat Ventricle
- Aortic Function (PWV) and Change of Vascular Wall Components:Comparison between WKY, SHRSR and SHRSP
- Effect of Surgical Sympathectomy on Acute Arterial Fat Deposition
- Ultrastructural Studies of Hypertensive Cerebrovascular Lesions
- Developmental change of T cell subsets in SHRSP:Analysis by Flow cytometry
- Experimental Studies on Atherogenesis:(II) Mechanism of Acute Arterial Fat Deposition in Hypertensive Rats
- Blood Pressure by New Tail Cuff Method in Spontaneously Hypertensive Rats (SHR)
- Bone Metabolism of SHRSP and its Characteristics as a Model for Spontaneous Osteoporosis
- Differences in the Developmental Modes of Cataract in WKY, SHR, SHRSP and Streptozotocin-treated SHR
- Beneficial Effect of Antihypertensive Therapy on Glucose Metabolism in Hypertensive Diabetic Rats
- Hypertensive Effects of Nitroarginine:Comparison between WKY and SHRSP
- EFFECT OF NORADRENALINE ON PROLIFERATION OF CULTURED SMOOTH MUSCLE CELLS FROM THE AORTA OF WISTAR KYOTO RATS (WKY), SPONTANEOUSLY HYPERTENSIVE RATS (SHR) AND STROKE-PRONE SHR (SHRSP)
- Genetical Disposition to Increase in Retinal Vascular Permeability under Ischemic Hypoxia in Stroke-Prone SHR (SHRSP) fed on Atherogenic Diet
- Hypophyseal Function in SHR:Lysine Incorporation and ACTH Content
- Effects of Growth Retardation during a Lactating Period on the Cerebral Maturation in Rats
- Effect of Sucrose and Sodium loading in Spontaneously Hypertensive Rats (SHR)
- Stroke Prevention by Dietary Protein, Calcium (Ca) and Magnesium (Mg) Supplementation in Salt-Loaded Stroke-Prone SHR (SHRSP)
- Correlation between Behavior and Blood Pressure in Offspring from Cross Breeding between Stroke-prone SHR(SHRSP) and Wistar-kyoto Rats (WKY)
- Interaction between Dietary Calcium and Sodium in Stroke-prone SHR (SHRSP)
- Genetical involvement of urinary calcium excretion in response to pregnancy as a stress in rats
- INSULIN RESISTANCE IN THE SPONTANEOUSLY HYPERTENSIVE RATS
- Linkage Analysis in Model Animals for Hypertension
- CHARACTERISTICS OF ATPase IN ERYTHROCYTES FROM SHR
- CHARACTERISTICS OF PLATELET AGGREGATION IN SHR AND OTHER VARIOUS STRAINS
- Electronmicroscopic autoradiographic study of the distribution of 3H-diltiazem in myocardial cells.
- Limited Value of Urinary Cotinine to Creatinine Ratio as an Indicator for Tobacco Smoke Exposure
- Aging and Dietary Effect on Glucose Tolerance (GT) in Stroke-Resistant Spontaneously Hypertensive Rats (SHRSR)
- Differential Platelet Function in SHRSP and SHR
- Effect of Salt Intake on Kidney Weight in Uninephrectomized Spontaneously Hypertensive Rats (SHR)
- Genetic and Environmental Influence on Cultured Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats (SHR)
- Ultrastructural Studies of Cerebral Arterial Lesions in Goldblatt's Renal Hypertensive Rats, Stroke-Prone SHR and Stroke-Prone SHR treated with L-NNA
- Autoregulation for Cerebral Blood Flow in Spontaneously Hypertensive Rats (SHR)
- Effect of Dilong on Blood Pressure in Spontaneous and Endothelium Derived Relaxing Factor(EDRF)-deficient Hypertension in Rats
- Effect of Fish Protein Rich Diet on Hypertension Induced by Dietary NG-nitro-L-arginine (L-NNA) in Normotensive Wistar Kyoto (WKY) Rats
- Blood Pressure in the offspring from cross breeding between strok-prone SHR (SHRSP) and Wistar-Kyoto (WKY)
- Characteristics of Bones in SHR as a Model of Spontaneously-induced Osteoporosis
- Effect of Lecithin-rich and Sucrose-rich Diets on the Development of Hypertension and the Incidence of Stroke in SHRSR Given 1% NaCl Water for Drinking
- Salt Intake and Intestinal Cholesterol Absorption
- Effects of NaCl loading on urinary Ca excretion in stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY)
- Calcium Ion Transport Abnormalities of Cultured Vascular Smooth Muscle Cells from Stroke-prone Spontaneously Hypertensive Rats in Hypoxia
- Comparative sequential morphological analyses during in vitro chondrogenesis and osteogenesis of mesenchymal stem cells embedded in collagen gels