Effect of High Fat Cholesterol Diet on Cerebrovascular Circulation and the Heart in Stroke-Prone SHR

概要

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The effect of high fat cholesterol diet (HFC diet) on cerebrovascular circulation was significant. I.e., at least at an early stage this diet lowered systemic blood pressure, thus leading to a reduced incidence of "arterionecro-thrombogenic" stroke by maintaining rCBF in normal range. Such result occurs despite clear ring-like fat deposition in the cerebrovascular system (Yamori et al: Stroke 7: 120, 1976), even though chemical cerebrovascular reactivity is reduced. This reduction of chemical cerebrovascular reactivity clearly indicates that fat deposits in cerebral arteries accelerate organic changes of cerebral arteries, i.e., cerebral arterio- or atherosclerosis.The above-mentioned HFC diet showed little significance in relation to the heart, either electrocardiographically and/or vectorcardiographically. This coincides with our previous report that the degree of myocardial fibrosis was not so remarkable as compared with the control groups. However, problems involving contents of the HFC diet, strain differences in SHR, and duration of feeding remained to be solved in the near future.
International Heart Journal刊行会の論文