Nonspecific Esterase Isozymes in the Cardiovascular System in Spontaneously Hypertensive Rats (SHR)

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Isoelectric focusing method revealed that the heart and aorta, but not choroid plexus and the cultured vascular smooth muscle cells, had obvious differences in nonspecific esterase isozyme patterns.The separation of the nonspecific esterase isozymes which were electrophoresed in the starch gel was already established as a method to detect a genetic marker of SHR (LAB INVEST 22: 206, 1970), but the separation of the isozyme pattern of the cardiovascular system was not so sufficiently clear. In contrast to the starch gel electrophoresis, the separation of the isozyme pattern by the isoelectric focusing was sufficient. Therefore, this technique can be regarded as a good method for analyzing nonspecific esterase isozymes and for detecting genetic markers of hypertensive strains.Although the pathogenic relationship between the different isozyme pattern and hypertensive diseases is not yet known from the present study, such a clear genetico-biochemical differences is suggestive of the possible existance of genetic factor of hypertension in the heart and blood vessels of SHR and SHRSP.
International Heart Journal刊行会の論文