Effect of Cervical Syrnpathectomy on Cerebrovascular Atherogenesis in SHR

概要

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Denervated groups clearly showed low susceptibility to fat deposition in the cerebrovascular system, as compared with the control group. However no significan differences were noted in blood pressure, gain in body weight and serum cholesterol levels. These results suggested the important role of innervation on fat deposition.On the other hand, our fluorescence microscopic study with concentrated glyoxylic acid immersion revealed that appearance of innervation in the basilar artery seemed to be spiral or ring-like, just as the fatty deposition produced by Yamori's preparation I, II, and III was detected as clear ring-like form.Further investigation into the relationship between innervation and ring-like sudanophylic rings in the cerebrovascular system should be required. However, the results reported here support and substantiate our previous assumption about the initiation mechanism of arterio- or atherosclerosis based on our experiments. I.e., the vicious circle of repeated vasodilatation and vasoconstriction-probably under the influence of nervous control-might be the basis for fatty degeneration resulting in cerebral arterio- or atherosclerosis.
International Heart Journal刊行会の論文