Pretreatment with Interleukin-1 Enhances Survival of Sympathetic Ganglionic Neuron Grafts
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概要
- 論文の詳細を見る
The effects of pretreatment with interleukin-1 (IL-1) on neurite growth and cell survival of rat superior cervical ganglion (SCG) explants were examined. Neonate rat SCG explants were cultured with serum-containing growth media. Pretreatment with IL-1β (30U/ml) for 3 hours stimulated neurite outgrowth of the SCG explant, which was inhibited by the addition of anti-nerve growth factor (NGF) antibody to the growth medium. Adult rat autologous SCG with the same pretreatment and non-treated ganglia were transplanted into the lateral ventricle. Histological evaluation of the grafts 2 weeks after transplantation revealed that the pretreated SCG cells survived better. Pretreatment with IL-1 may achieve the NGF-mediated neurotrophic effect in sympathetic ganglionic neurons resulting in enhanced graft survival.
- 日本脳神経外科学会の論文
- 1994-07-15
著者
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Itakura Toru
Department of Neurological Surgery, Wakayama Medical University
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Nakao Naoyuki
Department Of Neurological Surgery Wakayama Medical College:m.d. Department Of Neurology Restorative
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Nakao Naoyuki
Department Of Neurological Surgery Hidaka General Hospital
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Itakura Toru
Department Of Neurological Surgery Wakayama Medical University School Of Medicine
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Itakura Toru
Department Of Neurological Surgery Wakayama Medical College
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Furukawa Shoei
Department Of Molecular Biology Gifu Pharmaceutical University
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Komai Norihiko
Department Of Neurological Surgery Wakayama Medical College
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UEMATSU Yuji
Department of Neurological Surgery, Wakayama Medical College
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NAKAI Mitsukazu
Department of Neurological Surgery, Wakayama Medical College
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Uematsu Yuji
Department Of Neurological Surgery Wakayama Medical College
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Nakai Mitsukazu
Department Of Neurological Surgery Wakayama Medical College
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KOMAI Norihiko
Department of Neurological Surgery, Wakayama Medical College
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