A New Cognition-Enhancing Agent, (R)-(-)-1-(Benzo [b] thiophen-5-yl)-2-[2-(N, N-diethylamino) ethoxy] ethanol Hydrochloride. Effects on Memory Impairment in Rats Generated by Cerebral Embolization and Basal Forebrain Lesions
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概要
- 論文の詳細を見る
The title compound (T-588) has been evaluated for its ameliorating effect on memory impairment generated by cerebral embolization and by a basal forebrain (BF) lesion in male Wistar rats. The memory and learning deficits induced by injection of carbon-microspheres into the internal carotid artery were significantly improved by T-588 at oral dose of 3-10 mg/kg, as determined by an active avoidance response assay, whereas the reference drugs (tacrine, idebenone and indeloxazine) proved almost inactive in the same assay procedure. As far as the embolization was concerned, a significant decrease in cerebral acetylcholine and monoamines was observed. The effect on the memory impairment caused by an electrolytic lesion of the BF was assessed by a passive avoidance task. T-588 exhibited a bell-shaped dose-response curve and was most active at 1 mg/kg (oral dose), while tacrine showed equal activity at 10 mg/kg.
- 社団法人日本薬学会の論文
- 1995-12-15
著者
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小野 哲
富山化学工業株式会社綜合研究所
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藤堂 洋三
富山化学工業株式会社綜合研究所
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小野 哲
Research Laboratories, Toyama Chemical Co., Ltd.
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山藤 哲夫
Research Laboratories, Toyama Chemical Co., Ltd.
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茶木 久晃
Research Laboratories, Toyama Chemical Co., Ltd.
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藤堂 洋三
Research Laboratories, Toyama Chemical Co., Ltd.
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前川 睦子
Research Laboratories, Toyama Chemical Co., Ltd.
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北村 和則
Research Laboratories, Toyama Chemical Co., Ltd.
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木村 龍生
Research Laboratories, Toyama Chemical Co., Ltd.
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中田 恭史
Research Laboratories, Toyama Chemical Co., Ltd.
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最住 邦子
Research Laboratories, Toyama Chemical Co., Ltd.
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成田 弘和
Research Laboratories, Toyama Chemical Co., Ltd.
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前川 睦子
富山化学工業株式会社綜合研究所
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北村 和則
富山化学工業株式会社綜合研究所
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中田 吉孝
富山化学工業株式会社綜合研究所
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最住 邦子
富山化学工業株式会社綜合研究所
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木村 龍生
富山化学工業株式会社綜合研究所
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茶木 久晃
Research Laboratories Toyama Chemical Co. Ltd.
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藤堂 洋三
Research Laboratories Toyama Chemical Co. Ltd.
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Narita H
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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Kitamura Keisuke
Kyoto Pharmaceutical University
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中田 恭史
Research Laboratories Toyama Chemical Co. Ltd.
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山藤 哲夫
Research Laboratories Toyama Chemical Co. Ltd.
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Ono S
Graduate School Of Pharmaceutical Sciences Hokkaido University
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Kitamura K
Kyoto Pharmaceutical University
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北村 和則
Kyoto Pharmaceutical University
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