Preparation of new nitrogen-bridged heterocycles. 5. Smooth Michael additions of 2(3H)-indolizinone derivatives.
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概要
- 論文の詳細を見る
Michael additions of some 2(3<I>H</I>)-indolizinone derivatives to α,β-unsaturated nitriles, esters, and an amide gave the corresponding double Michael adducts, 3,3-disubstituted 2(3<I>H</I>)-indolizinones, in moderate to high yields, and those to methyl vinyl ketone afforded further condensed products, spiro[cyclohexane-1,3′(2′<I>H</I>)-indolizin]-2′-ones, instead of the expected 1:2 adducts. On the other hand, the reactions of the indolizinones with activated ethylenes having an appropriate leaving group at the β-position or with an acetylenic ester formed unstable 1:1 Michael adducts, which were converted to stable 2-acyloxy- or 2-alkoxy-3-vinylindolizine derivatives by the treatment with some acylating or alkylating agents in comparatively good yields.
- 公益社団法人 日本化学会の論文
著者
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Kakehi Akikazu
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Watanabe Kozo
Department Of Chemical Science And Technology Faculty Of Engineering The University Of Tokushima
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Nishimura Kenji
Department Of Biology Keio University School Of Medicine
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Ito Suketaka
Department of Applied Chemistry Faculty of Engineering Nagoya University
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Watanabe Kozo
Department of Industrial Chemistry, Faculty of Engineering, Shinshu University
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Wada Bunzo
Department of Industrial Chemistry, Faculty of Engineering, Shinshu University
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Kumagai Aiichiro
Department of Industrial Chemistry, Faculty of Engineering, Shinshu University
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Nishimura Kenji
Department of Industrial Chemistry, Faculty of Engineering, Shinshu University
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