Preparation of new nitrogen-bridged heterocycles. 25. A smooth synthesis of (1,4)thiazino(3,4,5-cd)indolizine derivatives.
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概要
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The title compounds were prepared smoothly in moderate yields by the reactions of 3-(mercaptomethylene)-2(3<I>H</I>)-indolizinones with various alkylating agents such as bromoacetonitrile, bromoacetates, and phenacyl bromides in the presence of base. The structural assignments of these products were accomplished by their spectral inspections, and the structure for one compound was distinctly proven by its X-ray crystallography. In order to explain the regioselectivity in this reaction, a molecular orbital calculation (CNDO/2) was also performed using a model compound.
- 公益社団法人 日本化学会の論文
著者
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Kakehi Akikazu
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Fujii Tsuneo
Department Of Chemistry And Materials Engineering Faculty Of Engineering Shinshu University
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Hatanaka Susumu
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Ito Suketaka
Department of Applied Chemistry Faculty of Engineering Nagoya University
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Mabuchi Toshiaki
Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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Urushido Kunio
Department of Chemistry, Faculty of Education, Shinshu University
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Sakurai Tosio
Department of Chemistry, Faculty of Education, Shinshu University
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Matsushita Shun-ichiro
Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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