Preparation of New Nitrogen-Bridged Heterocycles. 44. Thermolysis of 12bH-1,4-Thiazepino[5,4-a]isoquinoline Derivatives
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概要
- 論文の詳細を見る
Thermolysis of trialkyl 4-alkylthio-12bH-1,4-thiazepino[5,4-a]isoquinoline-1,2,5-tricarboxylates in refluxing xylene did not afford the usually expected desulfurized products such as benzoquinolizine derivatives (5), but formed trialkyl 2-(1-isoquinolinyl)-4-alkylthio-2,3-dihydrothiophene-2,3,5-tricarboxylates (4) in low to moderate yields. A similar treatment of the title compounds in the presence of a base such as 1,8-diazabicyclo[5.4.0]undec-7-ene gave ring contraction and fragmentation products, trialkyl pyrrolo[2,1-a]isoquinoline-1,2,3-tricarboxylates in moderate yields. 1,5-Sigmatropic shift of 7-thianorcardiene intermediates is involved in the formation of 2-(1-quinolinyl)-2,3-dihydrothiophene derivatives.
- 公益社団法人日本薬学会の論文
- 1998-06-15
著者
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Kakehi Akikazu
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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ITO Suketaka
Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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NISHIZAWA SATOSHI
Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine
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Ito Suketaka
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Nishizawa S
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Nishizawa Satoshi
Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University
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Ito Suketaka
Department of Applied Chemistry Faculty of Engineering Nagoya University
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