A New Approach to Imidazo[1,2-a]pyridine Derivatives and Their Application to the Syntheses of Novel 2H-Pyrano[2’,3’:4,5]imidazo[1,2-a]pyridin-2-one Derivatives
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概要
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3-[Bis(methylthio)methylene]-2(3H)-imidazo[1,2-a]pyridinones were prepared from the S-alkylation of pyridinium 1-[1-carbamoyl-1-[(methylthio) thiocarbonyl]]methylides with methyl iodide followed by the alkaline treatment of the resulting pyridinium salts. The reactions of these 3-methylene-2(3H)-imidazo[1,2-a]pyridinones with some ethyl cyano- or acyl-substituted acetates in the presence of a base did not afford the initially expected 2H-pyrano[2’,3’:4,5]imidazo[1,2-a]pyridine-2-one derivatives, but, instead of them, provided ethyl 3-[2-hydroxyimidazo[1,2-a]pyridin-3-yl]acrylates. The thermolyses of these acrylates without any solvent under reduced pressure gave the corresponding 2H-pyrano[2’,3’:4,5]imidazo[1,2-a]pyridine-2-one derivatives.
- 2010-01-01
著者
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Suga Hiroyuki
Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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Suga H
Department Of Physiology Ii Okayama University Medical School
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Kakehi A
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Suga Hiroyuki
Department Of Systems Physiology Okayama University Graduate School Of Medicine Dentistry And Pharma
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Akikazu Kakehi
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Suga H
Department Of Systems Physiology Okayama University Graduate School Of Medicine Dentistry And Pharma
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Suga Hiroyuki
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Kakehi A
Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855
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Suga Hiroyuki
Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855
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Suga Hiroyuki
Dep. Of Chemistry And Material Engineering Fac. Of Engineering Shinshu Univ. Wakasato Nagano 380-855
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