Biological Activities of Anthracycline Antibiotic SN-07 Chromophore and SN-07 Chromophore-DNA Complexes(Biological Chemistry)
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概要
- 論文の詳細を見る
The SN-07 chromophore is a unique anthracycline antibiotic which is a constituent of the new macromolecular antitumor antibiotic SN-07. SN-07 chromophore prevented growth of mouse lymphoid leukemia L1210 cells and Staphylococcus aureus 209P at concentrations of 0.016 and 100ng/ml, respectively. SN-07 chromophore inhibited DNA synthesis by 50% at 0.034μg/ml and RNA synthesis at 0.0125μg/ml in L1210 cells, and similarly at 0.075 and 0.130μg/ml in S. aureus, but did not inhibit protein synthesis in either cell type. These inhibition patterns indicate that SN-07 chromophore is a class I anthracycline antibiotic. We constructed two types of SN-07 chromophore-DNA complex, SN-07 chromophore-poly(dI-dC)・poly(dI-dC) complex (intercalation type) and SN-07 chromophore-poly(dG-dC)・poly(dG-dC) complex (covalent binding type), as models of the macromolecular antibiotic SN-07. The activities were different from those of free SN-07 chromophore in vitro and in vivo. Such a modification would represent a new drug delivery system for SN-07 chromophore.
- 社団法人日本農芸化学会の論文
- 1990-07-23
著者
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TAKAHASHI Hidetoshi
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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KIMURA Ken-ichi
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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MIYATA Nobuo
Research Institute of Life Science
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KAWANISHI Gosei
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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Kawanishi Gosei
Research Institute Of Life Science Snow. Brand Milk Products Co. Ltd.
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Kawanishi Gosei
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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TAKAOKA Hiroaki
Research Institute of Life Science, Snow. Brand Milk Products Co., Ltd.
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Kimura K
Research Institute Of Life Science
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Kimura K
Hokkaido Univ. Education Iwamizawa Jpn
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Takahashi H
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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Takaoka Hiroaki
Research Institute Of Life Science Snow. Brand Milk Products Co. Ltd.
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Takahashi Hidetoshi
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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Kimura Ken-ichi
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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