Inhibition of Ca^<2+>-Signal-Dependent Growth Regulation by Radicicol in Budding Yeast

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概要

• 論文の詳細を見る

• Compelled activation of Ca2+ signaling by exposure of zds1Δ strain Saccharomyces cerevisiae cells to external CaCl2 leads to characteristic physiological consequences such as growth inhibition in the G2 phase and polarized bud growth. Screening of microbial metabolites for activity alleviating the deleterious physiological effects of external CaCl2 identified the Hsp90 inhibitor radicicol as an inhibitor of Ca2+-signal-dependent cell-cycle regulation in yeast. Radicicol alleviated analogous physiological effects due to the expression of a constitutively active form of calcineurin or overexpression of Swe1, the negative regulatory kinase of the Cdc28-Clb complex. Western blot analysis indicated that radicicol inhibited Ca2+-induced accumulation of Swe1 and Cln2.

• 社団法人 日本農芸化学会の論文
• 2008-01-23

著者

• TAKAHASHI Hidetoshi

  Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.

• MIYAKAWA Tokichi

  Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni

• Takahashi H

  Tokyo Inst. Technol. Yokohama Jpn

• CHANKLAN Ruthada

  Department of Molecular Biotechnology, Graduate School of Advanced Science of Matter, Hiroshima Univ

• MIZUNUMA Masaki

  Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter (AdSM), Hirosh

• Mizunuma Masaki

  Dep. Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Univ.

• Mizunuma Masaki

  Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter (adsm) Hiroshim

• AIHARA Eiji

  Department of Biology, Faculty of Science, Shizuoka University

• Aihara Eiji

  Department Of Biology Faculty Of Science Shizuoka University

• KOGA Saori

  Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter,Hiroshima Univ

• Koga Saori

  Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive

• Aihara Eiji

  Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive

• Miyakawa Tokichi

  Dep. Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Univ.

• Miyakawa Tokichi

  Department Of Fermentation Technology Faculty Of Engineering Hiroshima University

• Chanklan Ruthada

  Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive

• Chanklan Ruthada

  Department Of Molecular Biotechnology Graduate School Of Advanced Science Of Matter Hiroshima Univer

• Miyakawa Tokichi

  Department Of Fermentation Technology

• Takahashi Hidetoshi

  Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.

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