Functional Analysis of the Promoter of the Yeast SNQ2 Gene Encoding a Multidrug Resistance Transporter that Confers the Resistance to 4-Nitroquinoline N-Oxide
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概要
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The yeast gene SNQ2,which encodes a multidrug resistance ABC superfamily protein, is required for resistance to the mutagen 4-nitroquinoline N-oxide (4-NQO). The expression of the SNQ2 gene is under the control of a regulatory network that involves the transcription factor Yrr1p, as well as Pdr1p/Pdr3p (Cui et al., Mol. Microbiol., 29,1307-1315(1998)). By 5'-deletion analysis of the promoter by using SNQ2-lacZ fusion constructs, four regions : -745 to -639 (region I), -639 to -578 (region II), -548 to -533 (region III) and -533 to -485 (region IV) were found to be important for SNQ2 expression. Genetic analysis suggested that the site in region IV was responsible for the Yrr1p-mediated SNQ2 expression. A consensus motif known for the binding of Pdr1p/Pdr3p (PDRE) was not found in region IV.
- 社団法人日本農芸化学会の論文
- 1999-01-23
著者
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HIRATA Dai
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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Hirata Dai
Department Of Molecular Biotechnology Faculty Of Engineering Hiroshima University
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Hirata Dai
Department Of Fermentation Technology Hiroshima University
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MIYAKAWA Tokichi
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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CUI ZHIFENG
Department of Fermentation Technology, Faculty of Engineering, Hiroshima University
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Cui Zhifeng
Department Of Molecular Biotechnology Faculty Of Engineering Hiroshima University
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Miyakawa Tokichi
Department Of Fermentation Technology Faculty Of Engineering Hiroshima University
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Miyakawa Tokichi
Department Of Molecular Biotechnology Faculty Of Engineering Hiroshima University
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Miyakawa Tokichi
Department Of Fermentation Technology
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CUI Zhifeng
Department of Bio-Geosciences, Osaka City University
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