Physiological Roles of Calcineurin in Saccharomyces cerevisiae with Special Emphasis on Its Roles in G_2/M Cell-Cycle Regulation
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概要
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Calcineurin, a highly conserved Ca2+/CaM-dependent protein phosphatase, plays key regulatory roles in diverse biological processes from yeast to humans. Genetic and molecular analyses of the yeast model system have proved successful in dissecting complex regulatory pathways mediated by calcineurin. Saccharomyces cerevisiae calcineurin is not essential for growth under laboratory conditions, but becomes essential for survival under certain stress conditions, and is required for stress-induced expression of the genes for ion transporters and cell-wall synthesis. Yeast calcineurin, in collaboration with a Mpk1 MAP kinase cascade, is also important in G2 cell-cycle regulation due to its action in a checkpoint-like mechanism. Genetic and molecular analysis of the Ca2+-dependent cell-cycle regulation has revealed an elaborate mechanism for the calcineurin-dependent regulation of the G2/M transition, in which calcineurin multilaterally activates Swe1, a negative regulator of the Cdc28/Clb complex, at the transcriptional, posttranslational, and degradation levels.
- 社団法人 日本農芸化学会の論文
- 2007-03-23
著者
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Mizunuma Masaki
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter (adsm) Hiroshim
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Miyakawa Tokichi
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
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Miyakawa Tokichi
Department Of Fermentation Technology
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Mizunuma Masaki
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
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