Pinostrobin from Boesenbergia pandurata Is an Inhibitor of Ca^<2+>-Signal-Mediated Cell-Cycle Regulation in the Yeast Saccharomyces cerevisiae

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概要

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• Upon searching plant extracts for inhibitors of the Ca2+ signaling pathway using the zds1Δ-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as active components. Further biochemical experiments confirmed that pinostrobin possesses inhibitory activity on the Ca2+ signals involved in the control of G2/M phase cell cycle progression in Saccharomyces cerevisiae.

• 社団法人 日本農芸化学会の論文
• 2009-07-23

著者

• Miyakawa Tokichi

  Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive

• Miyakawa Tokichi

  Department Of Fermentation Technology

• Chavasiri Warinthorn

  Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo

• KONGKATHIP Ngampong

  Department of Chemistry, Faculty of Science, Kasetsart University

• WANGKANGWAN Wachirasak

  Department of Microbiology, Faculty of Science, Chulalongkorn University

• BOONKERD Saipin

  Program in Biotechnology, Faculty of Science, Chulalongkorn University

• SUKAPIROM Kasama

  Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University

• PATTANAPANYASAT Kovit

  Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University

• YOMPAKDEE Chulee

  Department of Microbiology, Faculty of Science, Chulalongkorn University

• Boonkerd Saipin

  Program In Biotechnology Faculty Of Science Chulalongkorn University

• Kongkathip Ngampong

  Department Of Chemistry Faculty Of Science Kasetsart University

• Sukapirom Kasama

  Office For Research And Development Faculty Of Medicine Siriraj Hospital Mahidol University

• Wangkangwan Wachirasak

  Department Of Microbiology Faculty Of Science Chulalongkorn University

• Yompakdee Chulee

  Department Of Microbiology Faculty Of Science Chulalongkorn University

• Pattanapanyasat Kovit

  Office For Research And Development Faculty Of Medicine Siriraj Hospital Mahidol University

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