The Bisabolane Sesquiterpenoid Endoperoxide, 3, 6-Epidioxy-1, 10-bisaboladiene, Isolated from Cacalia delphiniifolia Inhibits the Growth of Human Cancer Cells and Induces Apoptosis

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概要

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• In the course of our screening for a new anti-tumor substance, the bisabolane sesquiterpenoid endoperoxide, 3,6-epidioxy-1,10-bisaboladiene (EDBD), was isolated from the edible wild-plant, Cacalia delphiniifolia. EDBD showed cytotoxicity toward human chronic myelogenous leukemia K562 and human prostate carcinoma LNCaP cell lines with IC50 values of 9.1 μM and 23.4 μM, respectively. DNA fragmentation and condensation of chromatin, the hallmarks of apoptosis, appeared in K562 cells after an 18-h treatment with EDBD. α-Curcumene, a bisabolane sesquiterpene that lacks the endoperoxide moiety of EDBD, also showed cytotoxicity toward both K562 and LNCaP cell lines at over a 10-times higher dose than that of EDBD. The results indicate the importance of the endoperoxide structure within EDBD to its anti-tumor activity in vitro.

• 社団法人 日本農芸化学会の論文
• 2008-09-23

著者

• Tsuchiya Eiko

  Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni

• KIMURA Ken-ichi

  Laboratory of Chemical Biology, Faculty of Agriculture, Iwate University

• Koshino Hiroyuki

  Advanced D & S Center Riken

• Tsuchiya Eiko

  Department Of Fermentation Technology Faculty Of Engineering Hiroshima University

• Yamada Kyohei

  Laboratory Of Chemical Biology Faculty Of Agriculture Iwate University

• NISHIKAWA Koji

  Laboratory of Chemical Biology, Faculty of Agriculture, Iwate University

• ABURAI Nobuhiro

  Laboratory of Chemical Biology, Faculty of Agriculture, Iwate University

• Koshino Hiroyuki

  Advanced Science Institute Riken

• Tsuchiya Eiko

  Department Of Molecular Biotechnology Graduate School Of Advanced Science Of Matter Hiroshima Univer

• Nishikawa Koji

  Laboratory Of Chemical Biology Faculty Of Agriculture Iwate University

• Kimura Ken-ichi

  Laboratory Of Chemical Biology Faculty Of Agriculture Iwate University

• Kimura Ken-ichi

  Laboratory Of Biology Sapporo Campus Hokkaido University Of Education

• Aburai Nobuhiro

  Lab. Of Chemical Biology The United Graduate School Of Agricultural Sciences Iwate Univ.

• Aburai Nobuhiro

  Laboratory Of Chemical Biology The United Graduate School Of Agricultural Sciences Iwate University

• Kimura Ken-ichi

  Faculty Of Agriculture Iwate University

• Aburai Nobuhiro

  Laboratory Of Chemical Biology Faculty Of Agriculture Iwate University

• KIMURA Ken-ichi

  Laboratory of Biochemistry, Deparment of Agricultural Chemistry, Tohoku University

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