Inhibition of 17α-Hydroxylase/C17,20-Lyase (CYP17) from Rat Testis by Green Tea Catechins and Black Tea Theaflavins
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概要
- 論文の詳細を見る
In the course of screening for 17α-hydroxylase/C17,20-lyase inhibitors from food ingredients, the methanol soluble fraction of green tea and black tea, which were expected to be rich in catechin and theaflavin content, showed potent inhibitory activity. (−)-Epigallocathechin gallate and theaflavin 3-O-gallate with a pirogallol moiety significantly inhibited C17,20-lyase activity on IC50 values of 24.5 μM and 11.5 μM respectively. They had potent cytotoxicity against human prostate cancer LNCaP cells (IC50=28.1 μM and 37.4 μM).
- 社団法人 日本農芸化学会の論文
著者
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KIMURA Ken-ichi
Laboratory of Chemical Biology, Faculty of Agriculture, Iwate University
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Yoshihama Makoto
Snow Brand Milk Products Co. Ltd.
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Kimura Ken-ichi
Laboratory Of Biology Sapporo Campus Hokkaido University Of Education
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GOTO Reika
Laboratory of Chemical Biology, Faculty of Agriculture, Iwate University
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TOJIMA Masato
Laboratory of Chemical Biology, Faculty of Agriculture, Iwate University
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EGAWA Nobumi
Laboratory of Chemical Biology, Faculty of Agriculture, Iwate University
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Goto Reika
Laboratory Of Chemical Biology Faculty Of Agriculture Iwate University
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Egawa Nobumi
Laboratory Of Chemical Biology Faculty Of Agriculture Iwate University
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Tojima Masato
Laboratory Of Chemical Biology Faculty Of Agriculture Iwate University
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Itakura Yoshie
Laboratory Of Chemical Biology Faculty Of Agriculture Iwate University
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KIMURA Ken-ichi
Laboratory of Biochemistry, Deparment of Agricultural Chemistry, Tohoku University
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